Global Patent Index - EP 1028747 A1

EP 1028747 A1 2000-08-23 - NOVEL IGF-I COMPOSITION AND ITS USE

Title (en)

NOVEL IGF-I COMPOSITION AND ITS USE

Title (de)

NEUE IGF-I ZUSAMMENSETZUNG UND IHRE VERWENDUNG

Title (fr)

NOUVELLE COMPOSITION D'IGF-I ET SON UTILISATION

Publication

EP 1028747 A1 (EN)

Application

EP 98957637 A

Priority

  • US 9823672 W
  • US 6489197 P
  • US 9608198 P

Abstract (en)

[origin: WO9924062A1] A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I concentration of at least about 250 mg/ml, a density of about 1.0 g/ml to about 1.2 g/ml, and a viscosity of about 13,000 centipoise (cps) to about 19,000 cps, as measured at ambient temperature (23 DEG C). The IGF-I syrup is prepared by precipitating or partitioning IGF-I from solution, preferably by adjusting the solution pH or by use of a solubility enhancer to concentrate IGF-I in solution followed by removal of the solubility enhancer. The precipitated syrup is useful as a means of storing IGF-I in a stable form and as a means of preparing compositions comprising biologically active IGF-I. Pharmaceutical compositions and kits comprising this concentrated IGF-I syrup are provided. The precipitated IGF-I syrup, IGF-I reconstituted from the IGF-I syrup, pharmaceutical compositions, and kits are useful in IGF-I therapy directed to IGF-I-responsive conditions.

IPC 1-7 (main, further and additional classification)

A61K 38/30

IPC 8 full level (invention and additional information)

A61K 9/06 (2006.01); A61K 9/16 (2006.01); A61K 38/27 (2006.01); A61K 38/30 (2006.01); A61P 43/00 (2006.01); C07K 1/30 (2006.01); C07K 14/65 (2006.01); A61K 9/00 (2006.01)

CPC (invention and additional information)

A61K 9/1647 (2013.01); A61K 9/1694 (2013.01); A61K 38/30 (2013.01); A61K 9/0024 (2013.01)

Citation (search report)

See references of WO 9924062A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9924062 A1 19990520; AU 1384799 A 19990531; EP 1028747 A1 20000823; JP 2001522813 A 20011120

INPADOC legal status


2004-10-13 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040409

2002-04-03 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020218

2000-08-23 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000517

2000-08-23 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE