Global Patent Index - EP 1028747 A1

EP 1028747 A1 20000823 - NOVEL IGF-I COMPOSITION AND ITS USE

Title (en)

NOVEL IGF-I COMPOSITION AND ITS USE

Title (de)

NEUE IGF-I ZUSAMMENSETZUNG UND IHRE VERWENDUNG

Title (fr)

NOUVELLE COMPOSITION D'IGF-I ET SON UTILISATION

Publication

EP 1028747 A1 20000823 (EN)

Application

EP 98957637 A 19981106

Priority

  • US 9823672 W 19981106
  • US 6489197 P 19971107
  • US 9608198 P 19980811

Abstract (en)

[origin: WO9924062A1] A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I concentration of at least about 250 mg/ml, a density of about 1.0 g/ml to about 1.2 g/ml, and a viscosity of about 13,000 centipoise (cps) to about 19,000 cps, as measured at ambient temperature (23 DEG C). The IGF-I syrup is prepared by precipitating or partitioning IGF-I from solution, preferably by adjusting the solution pH or by use of a solubility enhancer to concentrate IGF-I in solution followed by removal of the solubility enhancer. The precipitated syrup is useful as a means of storing IGF-I in a stable form and as a means of preparing compositions comprising biologically active IGF-I. Pharmaceutical compositions and kits comprising this concentrated IGF-I syrup are provided. The precipitated IGF-I syrup, IGF-I reconstituted from the IGF-I syrup, pharmaceutical compositions, and kits are useful in IGF-I therapy directed to IGF-I-responsive conditions.

IPC 1-7

A61K 38/30

IPC 8 full level

A61K 9/06 (2006.01); A61K 9/16 (2006.01); A61K 38/27 (2006.01); A61K 38/30 (2006.01); A61P 43/00 (2006.01); C07K 1/30 (2006.01); C07K 14/65 (2006.01); A61K 9/00 (2006.01)

CPC (source: EP)

A61K 9/1647 (2013.01); A61K 9/1694 (2013.01); A61K 38/30 (2013.01); A61P 43/00 (2017.12); A61K 9/0024 (2013.01)

Citation (search report)

See references of WO 9924062A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9924062 A1 19990520; AU 1384799 A 19990531; EP 1028747 A1 20000823; JP 2001522813 A 20011120

DOCDB simple family (application)

US 9823672 W 19981106; AU 1384799 A 19981106; EP 98957637 A 19981106; JP 2000520150 A 19981106