Global Patent Index - EP 1028971 A2

EP 1028971 A2 2000-08-23 - NOVEL CONJUGATES OF RGD-CONTAINING PEPTIDES AND ENDOGENOUS CARRIERS

Title (en)

NOVEL CONJUGATES OF RGD-CONTAINING PEPTIDES AND ENDOGENOUS CARRIERS

Title (de)

NEUE KONJUGATE VON RGD-ENTHALTENDEN PEPTIDEN UND ENDOGENEN TRÄGERN

Title (fr)

NOUVEAUX CONJUGUES DE PEPTIDES RENFERMANT RGD ET SUPPORTS ENDOGENES

Publication

EP 1028971 A2 (EN)

Application

EP 98957648 A

Priority

  • US 9823702 W
  • US 6470597 P

Abstract (en)

[origin: WO9924074A2] Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said antinociceptive agent with a material providing a functionally reactive group capable of reacting with a blood component (preferably a blood cell or protein). Said conjugates permit extension of the therapeutic life of the antinociceptive agent. They may be administered to patients to alleviate pain, produce analgesic effects, or assist in cases of narcotics withdrawal, and may also be used as probes for receptor activity. The administration to the patient may be made either in vivo or ex vivo and may be performed by either introducing the derivative including the reactive functional group into the patient's vascular system or preparing such a conjugate externally (or in vitro) and introducing that conjugate to the patient's vascular system.

IPC 1-7 (main, further and additional classification)

C07K 7/00

IPC 8 full level (invention and additional information)

A61K 35/16 (2006.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); A61P 7/02 (2006.01); A61P 25/04 (2006.01); A61P 43/00 (2006.01); C07K 7/08 (2006.01); C07K 14/665 (2006.01); C07K 14/75 (2006.01); C07K 14/78 (2006.01)

CPC (invention and additional information)

C07K 14/665 (2013.01); A61K 47/48246 (2013.01); A61K 47/48776 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9924462A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9924074 A2 19990520; WO 9924074 A3 19990819; AT 216402 T 20020515; AT 235513 T 20030415; AU 1312799 A 19990531; AU 1385699 A 19990531; AU 1519799 A 19990531; AU 750387 B2 20020718; CA 2301799 A1 19990520; CA 2301799 C 20070807; CA 2309205 A1 19990520; DE 69804974 D1 20020523; DE 69804974 T2 20021107; DE 69812727 D1 20030430; EP 1007561 A2 20000614; EP 1007561 B1 20020417; EP 1028971 A2 20000823; ES 2173641 T3 20021016; IL 135835 D0 20010520; JP 2001522817 A 20011120; JP 2001522863 A 20011120; WO 9924076 A2 19990520; WO 9924076 A3 19990819; WO 9924076 A9 20000608; WO 9924462 A2 19990520; WO 9924462 A3 19990826

INPADOC legal status


2003-08-06 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030131

2002-10-30 [RTI1] TITLE (CORRECTION)

- Free text: USE OF CONJUGATES OF RGD-CONTAINING PEPTIDES AND ENDOGENOUS CARRIERS

2002-10-09 [RTI1] TITLE (CORRECTION)

- Free text: USE OF CONJUGATES OF RGD-CONTAINING PEPTIDES AND ENDOGENOUS CARRIERS

2002-08-07 [RTI1] TITLE (CORRECTION)

- Free text: USE OF CONJUGATES OF RGD-CONTAINING PEPTIDES AND ENDOGENOUS CARRIERS

2001-02-28 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010116

2000-08-23 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000420

2000-08-23 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-08-23 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000420;LT PAYMENT 20000420;LV PAYMENT 20000420;MK PAYMENT 20000420;RO PAYMENT 20000420;SI PAYMENT 20000420