EP 1028971 A2 20000823 - NOVEL CONJUGATES OF RGD-CONTAINING PEPTIDES AND ENDOGENOUS CARRIERS
Title (en)
NOVEL CONJUGATES OF RGD-CONTAINING PEPTIDES AND ENDOGENOUS CARRIERS
Title (de)
NEUE KONJUGATE VON RGD-ENTHALTENDEN PEPTIDEN UND ENDOGENEN TRÄGERN
Title (fr)
NOUVEAUX CONJUGUES DE PEPTIDES RENFERMANT RGD ET SUPPORTS ENDOGENES
Publication
Application
Priority
- US 9823702 W 19981106
- US 6470597 P 19971107
Abstract (en)
[origin: WO9924074A2] Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said antinociceptive agent with a material providing a functionally reactive group capable of reacting with a blood component (preferably a blood cell or protein). Said conjugates permit extension of the therapeutic life of the antinociceptive agent. They may be administered to patients to alleviate pain, produce analgesic effects, or assist in cases of narcotics withdrawal, and may also be used as probes for receptor activity. The administration to the patient may be made either in vivo or ex vivo and may be performed by either introducing the derivative including the reactive functional group into the patient's vascular system or preparing such a conjugate externally (or in vitro) and introducing that conjugate to the patient's vascular system.
IPC 1-7
IPC 8 full level
A61K 35/16 (2006.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); A61P 7/02 (2006.01); A61P 25/04 (2006.01); A61P 43/00 (2006.01); C07K 7/08 (2006.01); C07K 14/665 (2006.01); C07K 14/75 (2006.01); C07K 14/78 (2006.01)
CPC (source: EP)
A61K 47/64 (2017.08); A61K 47/6901 (2017.08); A61P 7/02 (2018.01); A61P 25/04 (2018.01); A61P 29/00 (2018.01); A61P 43/00 (2018.01); C07K 14/665 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9924074 A2 19990520; WO 9924074 A3 19990819; AT E216402 T1 20020515; AT E235513 T1 20030415; AU 1312799 A 19990531; AU 1385699 A 19990531; AU 1519799 A 19990531; AU 750387 B2 20020718; CA 2301799 A1 19990520; CA 2301799 C 20070807; CA 2309205 A1 19990520; DE 69804974 D1 20020523; DE 69804974 T2 20021107; DE 69812727 D1 20030430; EP 1007561 A2 20000614; EP 1007561 B1 20020417; EP 1028971 A2 20000823; ES 2173641 T3 20021016; IL 135835 A0 20010520; JP 2001522817 A 20011120; JP 2001522863 A 20011120; WO 9924076 A2 19990520; WO 9924076 A3 19990819; WO 9924076 A9 20000608; WO 9924462 A2 19990520; WO 9924462 A3 19990826
DOCDB simple family (application)
US 9823704 W 19981106; AT 01121557 T 19981106; AT 98956656 T 19981106; AU 1312799 A 19981106; AU 1385699 A 19981106; AU 1519799 A 19981106; CA 2301799 A 19981106; CA 2309205 A 19981106; DE 69804974 T 19981106; DE 69812727 T 19981106; EP 98956656 A 19981106; EP 98957648 A 19981106; ES 98956656 T 19981106; IL 13583598 A 19981106; JP 2000520159 A 19981106; JP 2000520470 A 19981106; US 9823702 W 19981106; US 9823706 W 19981106