EP 1029041 A2 20000823 - HYPERTHERMIC INDUCIBLE EXPRESSION VECTORS FOR GENE THERAPY AND METHODS OF USE THEREOF
Title (en)
HYPERTHERMIC INDUCIBLE EXPRESSION VECTORS FOR GENE THERAPY AND METHODS OF USE THEREOF
Title (de)
HYPERTHERMISCHER INDUZIERBARER EXPRESSIONSVEKTOR FÜR GENTHERAPIE UND VERFAHREN ZUR IHRE VERWENDUNG
Title (fr)
VECTEURS D'EXPRESSION INDUCTIBLE PAR HYPERTHERMIE UTILES POUR LA THERAPIE GENIQUE ET PROCEDES D'UTILISATION DE CEUX-CI
Publication
Application
Priority
- US 9823387 W 19981103
- US 6408897 P 19971103
Abstract (en)
[origin: WO9923216A2] Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.
IPC 1-7
C12N 15/10; C12N 15/12; C12N 15/63; C07K 14/47; C12N 15/11; C12N 5/06; C12N 5/10; A61K 48/00
IPC 8 full level
A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01); C12P 21/00 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP KR)
A61K 48/00 (2013.01 - EP); A61P 35/00 (2017.12 - EP); C12N 15/10 (2013.01 - KR); C12N 15/63 (2013.01 - EP); C12N 15/85 (2013.01 - EP); C12N 2830/002 (2013.01 - EP); C12N 2830/85 (2013.01 - EP); C12N 2840/20 (2013.01 - EP)
Citation (search report)
See references of WO 9923216A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9923216 A2 19990514; WO 9923216 A3 19990805; AU 1377299 A 19990524; BR 9813917 A 20011030; CA 2308575 A1 19990514; CN 1299411 A 20010613; EP 1029041 A2 20000823; IL 135943 A0 20010520; JP 2001521740 A 20011113; KR 20010031762 A 20010416
DOCDB simple family (application)
US 9823387 W 19981103; AU 1377299 A 19981103; BR 9813917 A 19981103; CA 2308575 A 19981103; CN 98812752 A 19981103; EP 98957538 A 19981103; IL 13594398 A 19981103; JP 2000519075 A 19981103; KR 20007004827 A 20000503