Global Patent Index - EP 1029041 A2

EP 1029041 A2 2000-08-23 - HYPERTHERMIC INDUCIBLE EXPRESSION VECTORS FOR GENE THERAPY AND METHODS OF USE THEREOF

Title (en)

HYPERTHERMIC INDUCIBLE EXPRESSION VECTORS FOR GENE THERAPY AND METHODS OF USE THEREOF

Title (de)

HYPERTHERMISCHER INDUZIERBARER EXPRESSIONSVEKTOR FÜR GENTHERAPIE UND VERFAHREN ZUR IHRE VERWENDUNG

Title (fr)

VECTEURS D'EXPRESSION INDUCTIBLE PAR HYPERTHERMIE UTILES POUR LA THERAPIE GENIQUE ET PROCEDES D'UTILISATION DE CEUX-CI

Publication

EP 1029041 A2 (EN)

Application

EP 98957538 A

Priority

  • US 9823387 W
  • US 6408897 P

Abstract (en)

[origin: WO9923216A2] Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.

IPC 1-7 (main, further and additional classification)

C12N 15/10; A61K 48/00; C07K 14/47; C12N 5/06; C12N 5/10; C12N 15/11; C12N 15/12; C12N 15/63

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 5/10 (2006.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01); C12P 21/00 (2006.01); C12R 1/91 (2006.01)

CPC (invention and additional information)

C12N 15/63 (2013.01); A61K 48/00 (2013.01); C12N 15/85 (2013.01); C12N 2830/002 (2013.01); C12N 2830/85 (2013.01); C12N 2840/20 (2013.01)

Citation (search report)

See references of WO 9923216A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9923216 A2 19990514; WO 9923216 A3 19990805; AU 1377299 A 19990524; BR 9813917 A 20011030; CA 2308575 A1 19990514; CN 1299411 A 20010613; EP 1029041 A2 20000823; IL 135943 D0 20010520; JP 2001521740 A 20011113

INPADOC legal status


2003-12-03 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030601

2002-01-09 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV

- Ref Legal Event Code: RAP1

2000-08-23 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000531

2000-08-23 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE