EP 1029050 A1 20000823 - TUMOR-SPECIFIC ANTIGENS, METHODS FOR THEIR PRODUCTION AND THEIR USE FOR IMMUNIZATION AND DIAGNOSIS
Title (en)
TUMOR-SPECIFIC ANTIGENS, METHODS FOR THEIR PRODUCTION AND THEIR USE FOR IMMUNIZATION AND DIAGNOSIS
Title (de)
TUMOR-SPEZIFISCHE ANTIGENE, DEREN HERSTELLUNGSVERFAHREN UND ANWENDUNGEN ZUR IMPFUNG UND DIAGNOSE
Title (fr)
ANTIGENES SPECIFIQUES A UNE TUMEUR, PROCEDE DE PRODUCTION ET UTILISATION DE CES ANTIGENES POUR ASSURER UNE IMMUNISATION ET DIAGNOSTIC
Publication
Application
Priority
- EP 98965649 A 19981102
- EP 9806921 W 19981102
- EP 97119404 A 19971106
Abstract (en)
[origin: WO9924566A1] A tumor-specific polypeptidic antigen, which is coded at least partially by an intron of an exon-coded tumor antigen, and which is obtained by (a) reverse transcriptase PCR from mRNA isolated from the soluble cytoplasmic fraction of a tumor cell, whereby nucleic acid fragments which hybridize under stringent conditions with intron sequences of an exon-coded tumor antigens are used as a primer, (b) isolation of the product of said PCR, expression of said PCR product or of a fragment thereof in a host cell, and isolation of said tumor-specific antigen which is coded by said PCR product or a fragment thereof which hybridizes also with exon sequences of said antigen, is useful for diagnosis and therapeutic use in connection with tumor diseases.
IPC 1-7
C12N 15/12; C12N 15/10; C07K 14/705; C12Q 1/68; A61K 31/70; A61K 38/17
IPC 8 full level
A61K 31/70 (2006.01); A61K 31/711 (2006.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/12 (2006.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP KR)
A61P 35/00 (2017.12 - EP); C07K 14/00 (2013.01 - KR); C07K 14/4748 (2013.01 - EP); C07K 14/705 (2013.01 - EP); C12N 15/1034 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 48/00 (2013.01 - EP)
Citation (search report)
See references of WO 9924566A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9924566 A1 19990520; AR 017562 A1 20010912; AU 2151899 A 19990531; AU 743066 B2 20020117; BR 9813981 A 20000926; CA 2309557 A1 19990520; CN 1278865 A 20010103; EP 1029050 A1 20000823; JP 2001522603 A 20011120; KR 20010024585 A 20010326; TR 200001253 T2 20001121; ZA 9810130 B 19990506
DOCDB simple family (application)
EP 9806921 W 19981102; AR P980105575 A 19981105; AU 2151899 A 19981102; BR 9813981 A 19980102; CA 2309557 A 19981102; CN 98810896 A 19981102; EP 98965649 A 19981102; JP 2000520561 A 19981102; KR 20007004947 A 20000506; TR 200001253 T 19981102; ZA 9810130 A 19981105