Global patent index - EP 1029071 A1

EP 1029071 A1 2000-08-23 - PROCESS FOR PREPARING (2R,3S)-3-(4-LOWER ALKOXYPHENYL)GLYCIDIC ACID ESTERS

Title (en)

PROCESS FOR PREPARING (2R,3S)-3-(4-LOWER ALKOXYPHENYL)GLYCIDIC ACID ESTERS

Title (de)

VERFAHREN ZUR HERSTELLUNG VON (2R,3S)-3-(4-NIEDERALKOXYPHENIL)-GLYCIDSÄUREESTERN

Title (fr)

PROCEDE SERVANT A PREPARER DES ESTERS D'ACIDE (2R,3S)-3-(4-ALKOXYPHENYLE INFERIEUR)GLYCIDIQUE

Publication

EP 1029071 A1 (EN)

Application

EP 98950335 A

Priority

  • JP 9804776 W
  • JP 29468597 A

Abstract (en)

[origin: WO9922014A1] A novel process for preparing a (2R,3S)-3-(4-lower alkoxyphenyl)glycidic acid ester and a process for preparing a (2S,3S)-1,5-benzothiazepine compound, which is useful as a medicine, using the same are provided; and the (2R,3S)-3-(4-lower alkoxyphenyl)glycidic acid ester can be prepared by permitting a racemic trans-3-(4-lower alkoxyphenyl)glycidic acid ester to act on an amine compound in the presence of an enzyme derived from a microorganism belonging to the genus Serratia having the ability to asymmetrically amidate a (2S,3R)-3-(4-lower alkoxyphenyl)glycidic acid ester thereby stereoselectively amidating the (2S,3R) isomer, and then, separating and collecting a remaining (2R,3S)-3-(4-lower alkoxyphenyl)glycidic acid ester from a reaction mixture; and also the (2S,3S)-1,5-benzothiazepine compound can be prepared by permitting the resulting (2R,3S)-3-(4-lower alkoxyphenyl)glycidic acid ester to act on a 2-aminophenol compound, hydrolyzing a resulting compound, if necessary, then subjecting to intramolecular cyclization and O-alkanoylation, and, if desired, N-alkylation.

IPC 1-7 (main, further and additional classification)

C12P 41/00; C07D 281/10; C12P 17/02

IPC 8 full level (invention and additional information)

C12P 41/00 (2006.01); A61K 31/00 (2006.01); A61K 31/55 (2006.01); A61K 31/554 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); C07D 281/10 (2006.01); C07D 301/32 (2006.01); C07D 303/48 (2006.01); C12P 17/02 (2006.01); C12R 1/43 (2006.01)

CPC (invention and additional information)

C07D 303/48 (2013.01); C07D 281/10 (2013.01); C12P 17/02 (2013.01); C12P 41/006 (2013.01)

Citation (search report)

See references of WO 9922014A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9922014 A1 19990506; AU 9645898 A 19990517; CN 1273608 A 20001115; EP 1029071 A1 20000823; IL 135149 D0 20010520; JP 3252900 B2 20020204; JP H11192098 A 19990721

INPADOC legal status

2001-02-28 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20001229

2000-08-23 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000410

2000-08-23 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE