Global Patent Index - EP 1030557 A4

EP 1030557 A4 20020731 - PROTEIN DELIVERY BY SECRETORY GLAND EXPRESSION

Title (en)

PROTEIN DELIVERY BY SECRETORY GLAND EXPRESSION

Title (de)

PROTEINPRODUKTION DURCH EXPRESSION IN SEKRETORISCHE DRÜSEN

Title (fr)

ADMINISTRATION DE PROTEINES PAR L'EXPRESSION DES GLANDES SECRETOIRES

Publication

EP 1030557 A4 20020731 (EN)

Application

EP 98950707 A 19980924

Priority

  • US 9820199 W 19980924
  • US 94293997 A 19971002

Abstract (en)

[origin: WO9917610A1] Secretory gland cells, particularly pancreatic, hepatic, and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on a mammalian subject. The expressed protein is secreted directly into the bloodstream to obtain therapeutic levels of the protein thereby treating the patient in need of the protein. The transformed secretory gland cells provide long term or short term therapies for diseases associated with a deficiency in a particular protein or which are amenable to treatment by overexpression of a protein.

IPC 1-7

A01N 43/04; A01N 63/00; C12N 13/00; A61K 48/00

IPC 8 full level

C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61K 38/21 (2006.01); A61K 38/22 (2006.01); A61K 38/27 (2006.01); A61K 38/28 (2006.01); A61K 38/36 (2006.01); A61K 38/43 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 3/10 (2006.01)

CPC (source: EP)

A61K 38/27 (2013.01); A61K 38/28 (2013.01); A61P 3/10 (2017.12); A61K 48/00 (2013.01)

Citation (search report)

  • [X] WO 9630050 A1 19961003 - UNIV CALIFORNIA [US]
  • [X] KAGAMI H ET AL: "EVIDENCE FOR THE SYSTEMIC DELIVERY OF A TRANSGENE PRODUCT FROM SALIVARY GLANDS", HUMAN GENE THERAPY, XX, XX, vol. 7, 10 November 1996 (1996-11-10), pages 2177 - 2184, XP002915661, ISSN: 1043-0342
  • [A] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1981, MIYASAKA K ET AL: "ENDOCRINE SECRETION OF ALPHA AMYLASE BY THE PANCREAS", XP002197457, Database accession no. PREV198273016961 & AMERICAN JOURNAL OF PHYSIOLOGY, vol. 241, no. 2, 1981, pages G171 - G175, ISSN: 0002-9513
  • [PX] GOLDFINE IRA D ET AL: "The endocrine secretion of human insulin and growth hormone by exocrine gland of the gastrointestinal tract.", NATURE BIOTECHNOLOGY, vol. 15, no. 13, December 1997 (1997-12-01), pages 1378 - 1382, XP002197456, ISSN: 1087-0156
  • [A] SOSA-PINEDA B ET AL: "THE PAX4 GENE IS ESSENTIAL FOR DIFFERENTIATION OF INSULIN-PRODUCING BETA CELLS IN THE MAMMALIAN PANCREAS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 386, 27 March 1997 (1997-03-27), pages 399 - 402, XP002067725, ISSN: 0028-0836
  • See references of WO 9917610A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9917610 A1 19990415; AU 744279 B2 20020221; AU 9668998 A 19990427; CA 2304803 A1 19990415; EP 1030557 A1 20000830; EP 1030557 A4 20020731; JP 2001518316 A 20011016

DOCDB simple family (application)

US 9820199 W 19980924; AU 9668998 A 19980924; CA 2304803 A 19980924; EP 98950707 A 19980924; JP 2000514522 A 19980924