EP 1030684 A1 20000830 - MODIFIED ANTIBODIES WITH ENHANCED ABILITY TO ELICIT AN ANTI-IDIOTYPE RESPONSE
Title (en)
MODIFIED ANTIBODIES WITH ENHANCED ABILITY TO ELICIT AN ANTI-IDIOTYPE RESPONSE
Title (de)
MODIFIZIERTE ANTIKÖRPER MIT VERSTÄRKTER FÄHIGKEIT EINE ANTI-IDIOTYPISCHE ANTWORT AUSZULÖSEN
Title (fr)
ANTICORPS MODIFIES A CAPACITE AMELIOREE DE DECLENCHEMENT D'UNE REPONSE ANTI-IDIOTYPE
Publication
Application
Priority
- US 9824303 W 19981113
- US 6571697 P 19971114
- US 8140398 P 19980410
Abstract (en)
[origin: WO9925379A1] The invention relates to modified immunoglobulin molecules in which one or more variable region residues that form intrachain disulfide bonds are substituted with amino acid residues that do not contain sulfydryl groups, such that the intrachain disulfide bond does not form. Such immunoglobulin molecules have an enhanced ability to elicit an anti-idiotype response. The invention further provides for the methods of prevention and treatment of cancer and/or infectious diseases using the modified immunoglobulins of the invention.
IPC 1-7
A61K 39/395; C12N 5/12; C12N 15/13; C07K 16/42; C07K 16/08; C07K 16/12; C07K 16/20; C07K 16/30
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); C07K 7/18 (2006.01); C07K 16/00 (2006.01); C07K 16/08 (2006.01); C07K 16/12 (2006.01); C07K 16/20 (2006.01); C07K 16/30 (2006.01); C07K 16/42 (2006.01); C12N 5/10 (2006.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP KR)
A61K 39/395 (2013.01 - KR); A61P 31/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); C07K 7/18 (2013.01 - EP); C07K 16/00 (2013.01 - EP); C07K 16/3046 (2013.01 - EP); C07K 16/4266 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 39/00 (2013.01 - EP KR); A61K 2039/505 (2013.01 - EP); C07K 2317/565 (2013.01 - EP); C07K 2318/10 (2013.01 - EP); C07K 2319/00 (2013.01 - EP); Y02A 50/30 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9925379 A1 19990527; AU 1459799 A 19990607; AU 1459899 A 19990607; AU 2003252902 A1 20031106; AU 737457 B2 20010823; AU 763029 B2 20030710; BR 9815289 A 20011226; BR 9815580 A 20020129; CA 2309990 A1 19990527; CA 2310269 A1 19990527; CN 1294517 A 20010509; CN 1327388 A 20011219; EP 1030684 A1 20000830; EP 1030684 A4 20040915; EP 1032420 A1 20000906; EP 1032420 A4 20040915; IL 136113 A0 20010520; IL 136114 A0 20010520; JP 2001526021 A 20011218; JP 2002507544 A 20020312; KR 20010015817 A 20010226; KR 20010015818 A 20010226; WO 9925378 A1 19990527; WO 9925378 A9 19990812
DOCDB simple family (application)
US 9824303 W 19981113; AU 1459799 A 19981113; AU 1459899 A 19981113; AU 2003252902 A 20031010; BR 9815289 A 19981113; BR 9815580 A 19981113; CA 2309990 A 19981113; CA 2310269 A 19981113; CN 98813117 A 19981113; CN 98813119 A 19981113; EP 98958583 A 19981113; EP 98958584 A 19981113; IL 13611398 A 19981113; IL 13611498 A 19981113; JP 2000520811 A 19981113; JP 2000520812 A 19981113; KR 20007005263 A 20000515; KR 20007005264 A 20000515; US 9824302 W 19981113