Global patent index - EP 1030920 A1

EP 1030920 A1 2000-08-30 - METHODS FOR MODULATING NERVE CELL FUNCTION

Title (en)

METHODS FOR MODULATING NERVE CELL FUNCTION

Title (de)

VERFAHREN ZUR MODULATION DER NERVENZELLFUNKTION

Title (fr)

PROCEDES PERMETTANT DE MODULER UNE FONCTION DES CELLULES NERVEUSES

Publication

EP 1030920 A1 (EN)

Application

EP 98957960 A

Priority

  • US 9824327 W
  • US 6554397 P

Abstract (en)

[origin: WO9925833A1] The amount of active Robo expressed on a cell is modified by modulating the effective amount of a Comm polypeptide in contact with the cell, whereby the amount of expressed active Robo is modulated inversely with the modulation of the effective amount of the Comm polypeptide in contact with the cell. In a particular embodiment, the Comm polypeptide is provided to the cell exogenously in a pharmaceutically acceptable composition. In another aspect, the invention provides methods of screening for agents which modulate Robo-Comm interactions. These methods generally involve forming a mixture of a Robo-expressing cell, a Comm polypeptide and a candidate agent, and determining the effect of the agent on the amount of Robo expressed by the cell.

IPC 1-7 (main, further and additional classification)

C12N 15/18; A61K 38/18; C07K 14/475

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C07K 14/47 (2006.01); C07K 14/475 (2006.01); C12N 15/18 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 14/475 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9925833A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9925833 A1 19990527; AU 1409499 A 19990607; AU 745762 B2 20020328; CA 2306776 A1 19990527; EP 1030920 A1 20000830; JP 2001523458 A 20011127

INPADOC legal status

2002-12-11 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20021014

2000-08-30 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000515

2000-08-30 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE