Global Patent Index - EP 1030926 A2

EP 1030926 A2 2000-08-30 - TRANSGENIC MODELS OF INFLAMMATORY DISEASE

Title (en)

TRANSGENIC MODELS OF INFLAMMATORY DISEASE

Title (de)

TRANSGENMODELLE VON ENTZÜNDUNGSERKRANKUNGEN

Title (fr)

MODELES TRANSGENIQUES DE MALADIES INFLAMMATOIRES

Publication

EP 1030926 A2 (EN)

Application

EP 98962809 A

Priority

  • GB 9723835 A
  • US 9824287 W

Abstract (en)

[origin: WO9925857A2] The present provides a mammal in which the expression of one or more interleukin genes has been suppressed. More specifically, the invention concerns the inactivating deletion of the interleukin-1 receptor antagonist gene to produce a knock-out non-human mammal with decreased or completely suppressed expression of the endogenous gene. The invention provides methods for preparing such knock-out mammals and methods of using the knock-out mammals to evaluate the effectiveness of therapeutic agents and regimens to treat diseases or disorders associated with perturbations in the interleukin pathways.

IPC 1-7 (main, further and additional classification)

C12N 15/85; A01K 67/027; A61K 49/00; C07K 14/54; C12N 5/10

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A61K 45/00 (2006.01); A61K 49/00 (2006.01); C07K 14/54 (2006.01); C07K 14/545 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01)

CPC (invention and additional information)

C07K 14/54 (2013.01); A01K 67/0276 (2013.01); C12N 15/8509 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0325 (2013.01); A01K 2267/0368 (2013.01); C12N 2800/30 (2013.01)

Citation (search report)

See references of WO 9925857A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9925857 A2 19990527; WO 9925857 A3 19990715; AU 1796699 A 19990607; BR 9814142 A 20001003; CA 2309807 A1 19990527; EP 1030926 A2 20000830; GB 9723835 D0 19980107; HU 0004352 A2 20010328; IL 136013 D0 20010520; JP 2001523467 A 20011127; NO 20002477 A 20000712; NO 20002477 D0 20000512; PL 340829 A1 20010226; TR 200001356 T2 20000821

INPADOC legal status


2006-05-10 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051102

2005-06-08 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050420

2000-11-29 [RAP3] CORRECTION OF THE ADDRESS OR NAME OF APPLICANT (A DOCUMENT)

- Owner name: INTERLEUKIN GENETICS, INC.

2000-08-30 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000608

2000-08-30 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE