Global Patent Index - EP 1032385 A1

EP 1032385 A1 2000-09-06 - USE OF SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELLPROLIFERATION, DIARRHE AND SCOURS

Title (en)

USE OF SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELLPROLIFERATION, DIARRHE AND SCOURS

Title (de)

VERWENDUNG VON SUBSTITUIERTEN DIPHENYL INDANONE, INDAN UND INDOL DERIVATE ZUR BEHANDLUNG ODER VORBEUGUNG VON SICHELZELLANÄMIE, ENTZÜNTLICHEN ERKRANKUNGEN, DIE DURCH ABNORMALE ZELLPROLIFERATION GEKENZEICHNET SIND, DIARRHÖE UND DIARRHÖE BEI TIEREN

Title (fr)

UTILISATION DE COMPOSES DE DIPHENYLE INDANONE, INDANE ET INDOLE SUBSTITUES DANS LE TRAITEMENT OU LA PREVENTION DE LA DREPANOCYTOSE, DES MALADIES INFLAMMATOIRES CARACTERISEES PAR UNE PROLIFERATION CELLULAIRE ANORMALE ET PAR LA DIARRHEE CHEZ L'HOMME ET L'ANIMAL

Publication

EP 1032385 A1 (EN)

Application

EP 98960381 A

Priority

  • US 9824968 W
  • US 97559597 A
  • US 15933698 A
  • US 15933198 A

Abstract (en)

[origin: WO9926624A1] The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof which are specific, potent and safe inhibitors of the Ca<2+>-activated potassium channel (Gardos channel) of erythrocytes, of mammalian cell proliferation and/or of secretagogue-stimulated transepithelial electrogenic chloride secretion in intestinal cells. The compounds can be used to reduce sickle erytrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation in situ as a therapeutic approach towards the treatment or prevention of sickle cell disease. The compounds can also be used to inhibit mamalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation. Furthermore, the compounds can also be used to inhibit chloride secretion in intestinal cells as a therapeutic approach towards the treatment of diarrhea and scours.

IPC 1-7 (main, further and additional classification)

A61K 31/40; A61K 31/015; C07C 13/465

IPC 8 full level (invention and additional information)

C07D 317/20 (2006.01); A61K 31/045 (2006.01); A61K 31/075 (2006.01); A61K 31/12 (2006.01); A61K 31/122 (2006.01); A61K 31/15 (2006.01); A61K 31/165 (2006.01); A61K 31/216 (2006.01); A61K 31/222 (2006.01); A61K 31/235 (2006.01); A61K 31/277 (2006.01); A61K 31/336 (2006.01); A61K 31/357 (2006.01); A61K 31/403 (2006.01); A61K 31/404 (2006.01); A61K 35/20 (2006.01); A61P 1/00 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 17/00 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07D 209/14 (2006.01)

CPC (invention and additional information)

A61K 31/165 (2013.01); A61K 31/045 (2013.01); A61K 31/075 (2013.01); A61K 31/122 (2013.01); A61K 31/15 (2013.01); A61K 31/216 (2013.01); A61K 31/222 (2013.01); A61K 31/235 (2013.01); A61K 31/277 (2013.01); A61K 31/336 (2013.01); A61K 31/357 (2013.01); A61K 31/404 (2013.01); A61K 35/20 (2013.01)

Combination set (CPC)

A61K 35/20 + A61K 2300/00

Citation (search report)

See references of WO 9926624A1

Designated contracting state (EPC)

AT BE CH DE ES FR GB IE IT LI LU NL PT SE

EPO simple patent family

WO 9926624 A1 19990603; AU 1598899 A 19990615; CA 2311129 A1 19990603; EP 1032385 A1 20000906; IL 136208 D0 20010520; JP 2001523717 A 20011127

INPADOC legal status


2002-12-18 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020601

2001-02-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: BRUGNARA, CARLO

2001-02-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: HALPERIN, JOSE

2001-02-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: BELLOT, EMILE, M., JR.

2001-02-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: FROIMOWITZ, MARK

2001-02-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: LOMBARDY, RICHARD, JOHN

2001-02-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: CLIFFORD, JOHN, J.

2001-02-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: GAO, YING-DUO

2001-02-07 [RIN1] INVENTOR (CORRECTION)

- Inventor name: HAIDAR, REEM, M.

2000-09-06 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000616

2000-09-06 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE ES FR GB IE IT LI LU NL PT SE