Global Patent Index - EP 1032588 A1

EP 1032588 A1 2000-09-06 - INTERACTION OF ALPHA-CONOTOXIN PEPTIDES WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS

Title (en)

INTERACTION OF ALPHA-CONOTOXIN PEPTIDES WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS

Title (de)

WECHSELWIRKUNG VON ALPHA-CONOTOXINPEPTIDEN MIT NEURONALEN NIKOTINISCHEN ACETYLCHOLIN REZEPTOREN

Title (fr)

INTERACTION DE PEPTIDES D'ALPHA-CONOTOXINE AVEC DES RECEPTEURS NEURAUX D'ACETYLCHOLINE NICOTINIQUE

Publication

EP 1032588 A1 (EN)

Application

EP 98953885 A

Priority

  • US 9822368 W
  • US 6278397 P
  • US 6581497 P

Abstract (en)

[origin: WO9921878A1] This invention relates to derivatives of the conopeptide MII, an alpha -4/7 conotoxin peptide, in which amino acid residues are substituted as described herein while maintaining the basic activity of MII. The present invention also relates to the discovery of the 3-dimensional structure of MII, and the relationship of its structure to its specificity to the alpha 3 beta 2 subtype of the neuronal nicotinic acetylcholine receptor (nAChR). The present invention also relates to computer based programs for the expression of the three-dimensional structure of MII and peptide analogs, peptide mimetics or non-peptide mimetics thereof. The structural characteristics may be correlated with biological activity to enable the design of alpha -4/7 conotoxin peptide analogs and peptide mimetics which demonstrate the same specificity to neuronal nAChR. Such analogs and peptide mimetics are useful as cardiovascular agents and for treating or detecting small-cell lung carcinoma (SCLC).

[origin: WO9921878A1] This invention relates to derivatives of the conopeptide MII, an alpha -4/7 conotoxin peptide, in which amino acid residues are substituted as described herein while maintaining the basic activity of MII. The present invention also relates to the discovery of the 3-dimensional structure of MII, and the relationship of its structure to its specificity to the alpha 3 beta 2 subtype of the neuronal nicotinic acetylcholine receptor (nAChR). The present invention also relates to computer based programs for the expression of the three-dimensional structure of MII and peptide analogs, peptide mimetics or non-peptide mimetics thereof. The structural characteristics may be correlated with biological activity to enable the design of alpha -4/7 conotoxin peptide analogs and peptide mimetics which demonstrate the same specificity to neuronal nAChR. Such analogs and peptide mimetics are useful as cardiovascular agents and for treating or detecting small-cell lung carcinoma (SCLC).

IPC 1-7 (main, further and additional classification)

C07K 7/08; G01N 24/08; G01N 33/68; G06F 17/30; G06F 19/00

IPC 8 full level (invention and additional information)

G01R 33/465 (2006.01); C07K 7/08 (2006.01); C07K 14/435 (2006.01); C12N 15/09 (2006.01); G01N 33/566 (2006.01); G01N 33/574 (2006.01); G06F 17/30 (2006.01); G06F 19/00 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

G01N 33/566 (2013.01); C07K 14/43504 (2013.01); G01N 33/57423 (2013.01); A61K 38/00 (2013.01); G01N 2333/43504 (2013.01); G01N 2333/4756 (2013.01); G01N 2333/70571 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9921878 A1 19990506; AU 1114399 A 19990517; CA 2308115 A1 19990506; EP 1032588 A1 20000906; EP 1032588 A4 20011128; JP 2001521042 A 20011106

INPADOC legal status


2002-07-31 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020103

2001-11-28 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20011016

2001-11-28 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-09-06 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000522

2000-09-06 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE