EP 1032663 A1 20000906 - METHODS FOR IDENTIFYING THE TOXIC/PATHOLOGIC EFFECT OF ENVIRONMENTAL STIMULI ON GENE TRANSCRIPTION
Title (en)
METHODS FOR IDENTIFYING THE TOXIC/PATHOLOGIC EFFECT OF ENVIRONMENTAL STIMULI ON GENE TRANSCRIPTION
Title (de)
VERFAHREN ZUR ERKENNUNG UMWELTBEDINGTEN TOXIKOLOGISCH ODER PATHOLOGISCHE WIRKUNGEN AUF DIE GENEXPRESSION
Title (fr)
PROCEDE D'EVALUATION DES EFFETS TOXIQUES ET PATHOLOGIQUES DE STIMULI ENVIRONNEMENTAUX SUR LA TRANSCRIPTION DES GENES
Publication
Application
Priority
- GB 9803445 W 19981120
- US 6624197 P 19971120
Abstract (en)
[origin: WO9927090A1] Methods are disclosed for assessing the toxic or pathologic effects of a selected environmental stimulus or reagent on a mammalian cell by determining on a DNA grid a "fingerprint" hybridization pattern. The fingerprint pattern is characteristic of chemically or structurally diverse stimuli or reagents, which have a common adverse effect on gene transcription. A test compound is screened for a similar toxic effect by comparing its hybridization pattern on a similar grid to the fingerprint.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C07K 14/47 (2006.01); C12N 15/12 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6809 (2018.01); C12Q 1/6837 (2018.01)
CPC (source: EP)
C12Q 1/6809 (2013.01); C12Q 1/6837 (2013.01)
Citation (search report)
See references of WO 9927090A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9927090 A1 19990603; AU 1166199 A 19990615; CA 2310621 A1 19990603; EP 1032663 A1 20000906; JP 2001524311 A 20011204
DOCDB simple family (application)
GB 9803445 W 19981120; AU 1166199 A 19981120; CA 2310621 A 19981120; EP 98954606 A 19981120; JP 2000522232 A 19981120