Global patent index - EP 1032663 A1

EP 1032663 A1 2000-09-06 - METHODS FOR IDENTIFYING THE TOXIC/PATHOLOGIC EFFECT OF ENVIRONMENTAL STIMULI ON GENE TRANSCRIPTION

Title (en)

METHODS FOR IDENTIFYING THE TOXIC/PATHOLOGIC EFFECT OF ENVIRONMENTAL STIMULI ON GENE TRANSCRIPTION

Title (de)

VERFAHREN ZUR ERKENNUNG UMWELTBEDINGTEN TOXIKOLOGISCH ODER PATHOLOGISCHE WIRKUNGEN AUF DIE GENEXPRESSION

Title (fr)

PROCEDE D'EVALUATION DES EFFETS TOXIQUES ET PATHOLOGIQUES DE STIMULI ENVIRONNEMENTAUX SUR LA TRANSCRIPTION DES GENES

Publication

EP 1032663 A1 (EN)

Application

EP 98954606 A

Priority

  • GB 9803445 W
  • US 6624197 P

Abstract (en)

[origin: WO9927090A1] Methods are disclosed for assessing the toxic or pathologic effects of a selected environmental stimulus or reagent on a mammalian cell by determining on a DNA grid a "fingerprint" hybridization pattern. The fingerprint pattern is characteristic of chemically or structurally diverse stimuli or reagents, which have a common adverse effect on gene transcription. A test compound is screened for a similar toxic effect by comparing its hybridization pattern on a similar grid to the fingerprint.

IPC 1-7 (main, further and additional classification)

C12N 15/12; C07K 14/47; C12Q 1/68

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C07K 14/47 (2006.01); C12N 15/12 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12Q 1/6809 (2013.01); C12Q 1/6837 (2013.01)

Citation (search report)

See references of WO 9927090A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9927090 A1 19990603; AU 1166199 A 19990615; CA 2310621 A1 19990603; EP 1032663 A1 20000906; JP 2001524311 A 20011204

INPADOC legal status

2007-06-06 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20050906

2002-09-04 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: SMITHKLINE BEECHAM CORPORATION

- Ref Legal Event Code: RAP1

2002-09-04 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: SMITHKLINE BEECHAM PLC

- Ref Legal Event Code: RAP1

2000-09-06 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000613

2000-09-06 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE