EP 1034162 A1 20000913 - 9,10-DIHYDRO-9,10-ETHANOANTHRACENE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS
Title (en)
9,10-DIHYDRO-9,10-ETHANOANTHRACENE DERIVATIVES AS PHOSPHOLIPASE INHIBITORS
Title (de)
9,10-DIHYDRO-9,10-ETHANOANTHRACENDERIVATE ALS PHOSPHOLIPASE-INHIBITOREN
Title (fr)
DERIVES DE 9,10-DIHYDRO-9,10-ETHANOANTHRACENE UTILISES COMME INHIBITEURS DE PHOHSPHOLIPASE
Publication
Application
Priority
- DE 19742014 A 19970924
- EP 9806096 W 19980924
Abstract (en)
[origin: DE19742014A1] New and known tetracyclo(6.6.2.0<2>,7.09,14)hexadeca- 2(7),3,5,9(14),10,12-hexaene derivatives (I) are used for preparation of medicaments with phospholipase-inhibiting activity. Use of tetracyclo(6.6.2.0<2>,7.09,14)hexadeca- 2(7),3,5,9(14),10,12-hexaene derivatives of formula (I), and salts, esters, optically active forms, racemates or derivatives which are metabolized to compounds of formula (I) in vivo, in preparation of a medicament with phospholipase-inhibiting activity, is new. R1, R2 = H or halo; X = H; Y = NR3R4 or N<+>CH3R3R4; or X + Y = CH2-NR<5> (sic); Z = CH2 or C=NH; R3 = H or lower alkyl; R4 = OH, carbamoyl, amidino, heteroaryl, N-aralkylheteroaryl or lower alkyl; or NR3R4 = a heterocyclic ring which optionally contains a second heteroatom and is optionally substituted; R5 = H, amidino, or a heterocyclic group which contains one or more heteroatoms An Independent claim is included for the compounds of formula (I), provided that when R1 and R2 are both H, then (a) R4 is not lower alkyl; (b) R5 is not H; (c) NR3R4 is not an unsubstituted piperidine or morpholine ring.
IPC 1-7
C07C 211/31; C07C 211/63; C07C 251/18; C07C 275/24; C07C 279/04; C07C 279/06; A61K 31/155; C07D 209/72; C07D 211/58; C07D 213/74; C07D 233/48; C07D 295/073; C07D 403/04; A61K 31/135; A61K 31/14
IPC 8 full level
A61K 31/131 (2006.01); A61K 31/135 (2006.01); A61K 31/14 (2006.01); A61K 31/155 (2006.01); A61K 31/17 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/4164 (2006.01); A61K 31/4178 (2006.01); A61K 31/4409 (2006.01); A61K 31/4453 (2006.01); A61K 31/4468 (2006.01); A61K 31/5375 (2006.01); A61P 1/04 (2006.01); A61P 1/18 (2006.01); A61P 9/02 (2006.01); A61P 11/00 (2006.01); A61P 17/00 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 37/06 (2006.01); A61P 37/08 (2006.01); C07C 211/31 (2006.01); C07C 211/63 (2006.01); C07C 233/58 (2006.01); C07C 255/47 (2006.01); C07C 259/16 (2006.01); C07C 275/22 (2006.01); C07C 275/24 (2006.01); C07C 279/04 (2006.01); C07D 209/02 (2006.01); C07D 209/56 (2006.01); C07D 209/80 (2006.01); C07D 211/58 (2006.01); C07D 213/74 (2006.01); C07D 233/48 (2006.01); C07D 233/50 (2006.01); C07D 295/06 (2006.01); C07D 295/073 (2006.01); C07D 403/04 (2006.01)
CPC (source: EP KR)
A61P 1/04 (2017.12 - EP); A61P 1/18 (2017.12 - EP); A61P 9/02 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 37/08 (2017.12 - EP); C07C 211/31 (2013.01 - EP KR); C07C 233/58 (2013.01 - EP); C07C 255/47 (2013.01 - EP); C07C 259/16 (2013.01 - EP); C07C 275/22 (2013.01 - EP); C07C 279/04 (2013.01 - EP); C07D 209/80 (2013.01 - EP); C07D 211/58 (2013.01 - EP); C07D 213/74 (2013.01 - EP); C07D 233/50 (2013.01 - EP); C07D 295/073 (2013.01 - EP); C07C 2603/88 (2017.04 - EP)
Citation (search report)
See references of WO 9915493A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
DE 19742014 A1 19990325; AR 019256 A1 20020213; AU 9746698 A 19990412; BR 9813217 A 20000829; CA 2304879 A1 19990401; CN 1278789 A 20010103; EP 1034162 A1 20000913; JP 2002505999 A 20020226; KR 20010024258 A 20010326; TR 200001222 T2 20000921; WO 9915493 A1 19990401; WO 9915493 A8 19990506; ZA 988711 B 20000323
DOCDB simple family (application)
DE 19742014 A 19970924; AR P980104764 A 19980923; AU 9746698 A 19980924; BR 9813217 A 19980924; CA 2304879 A 19980924; CN 98811160 A 19980924; EP 9806096 W 19980924; EP 98951464 A 19980924; JP 2000512804 A 19980924; KR 20007003134 A 20000323; TR 200001222 T 19980924; ZA 988711 A 19980923