Global Patent Index - EP 1034163 A1

EP 1034163 A1 2000-09-13 - NEW CYSTEINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICALS CONTAINING THEM

Title (en)

NEW CYSTEINE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICALS CONTAINING THEM

Title (de)

CYSTEINDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE ENTHALTENDE ARZNEIMITTEL

Title (fr)

NOUVEAUX DERIVES DE CYSTEINE, LEURS PROCEDES DE PRODUCTION ET PRODUITS PHARMACEUTIQUES LES CONTENANT

Publication

EP 1034163 A1 (EN)

Application

EP 98924281 A

Priority

  • EP 98924281 A
  • EP 9802654 W
  • EP 97107495 A

Abstract (en)

[origin: WO9850351A1] A compound represented by general formula (I), which binds and inhibits matrix metalloproteinases (MMPs), wherein the cysteine moiety contains an unprotected thiol group, the cysteine moiety is in the L- or D-configuration wherein A denotes -CO-, SO2-, -NH-CO-, or -O-CO-, R1 denotes hydrogen, a linear or branched saturated or unsaturated alkyl group of 1 to 15 carbon atoms or a C1-C15 alkyl group substituted by halogen, mercapto, hydroxy, alkoxy, amino or nitro, or by carbocyclic non aromatic or aromatic ring systems which are optionally substituted once or several times or aromatic or non aromatic heterocycles, optionally substituted, their pharmacologically acceptable salts, or optically active forms thereof. R denotes hydroxy, a linear or branched saturated or unsaturated alkyl group of 1 to 15 carbon atoms or a C1-C15 alkyl group substituted by carbocyclic non aromatic or aromatic ring systems which are optionally substituted once or several times or aromatic or non aromatic heterocycles, optionally substituted, their pharmacologically acceptable salts, or optically active forms thereof, processes for the preparation, pharmaceutical compositions and their use in medicine.

IPC 1-7 (main, further and additional classification)

C07C 323/60; A61K 31/16; A61K 31/27; A61K 31/40; A61K 31/44; C07D 209/16; C07D 213/40

IPC 8 full level (invention and additional information)

C07D 213/56 (2006.01); A61K 31/16 (2006.01); A61K 31/27 (2006.01); A61K 31/40 (2006.01); A61K 31/405 (2006.01); A61K 31/44 (2006.01); A61K 31/4409 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07C 323/60 (2006.01); C07D 209/16 (2006.01); C07D 213/40 (2006.01)

CPC (invention and additional information)

C07D 213/40 (2013.01); C07C 323/60 (2013.01); C07D 209/16 (2013.01)

Citation (search report)

See references of WO 9850351A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9850351 A1 19981112; AU 7652998 A 19981127; BR 9808758 A 20001003; CA 2289094 A1 19981112; CN 1261878 A 20000802; EP 1034163 A1 20000913; JP 2001525800 A 20011211; KR 20010012321 A 20010215; TR 9903120 T2 20000522; ZA 9803792 B 19991108

INPADOC legal status


2003-04-16 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020926

2002-07-03 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020515

2000-09-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000228

2000-09-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE