Global Patent Index - EP 1034176 A1

EP 1034176 A1 2000-09-13 - THIOPHENE-SULFONAMIDE COMPOUNDS

Title (en)

THIOPHENE-SULFONAMIDE COMPOUNDS

Title (de)

THIOPHENSULFONAMIDE DERIVATE

Title (fr)

COMPOSES THIOPHENE-SULFAMIDES

Publication

EP 1034176 A1 (EN)

Application

EP 98961128 A

Priority

  • EP 9806993 W
  • GB 9725138 A

Abstract (en)

[origin: WO9928316A1] Compounds of formula (I) wherein X is O or S; each of R, R1, and R2, which are the same or different, is independently hydrogen, halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino, C1-C6 alkoxy-carbonyl, or an unsaturated pentatomic heteromonocyclic ring containing one to three heteroatoms chosen independently from oxygen, sulphur and nitrogen, wherein the heteromonocyclic ring is unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; R3 is hydrogen, C1-C6 alkyl or a phenyl or benzyl group, in which the phenyl ring or phenyl moiety is unsubstitutedor substituted by one or two substituents chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino and C1-C6 alkoxy-carbonyl; each of R4 and R5, which are the same or different, is independently hydrogen or a phenyl ring unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; or R4 and R5 taken together form a C6-C14 aromatic ring system unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; and the pharmaceutically acceptable salts thereof have kynurenine-3-hydroxylase enzyme inhibitory activity.

IPC 1-7 (main, further and additional classification)

C07D 413/14; A61K 31/42; A61K 31/425; C07D 413/12; C07D 417/12; C07D 417/14

IPC 8 full level (invention and additional information)

A61K 31/422 (2006.01); A61K 31/423 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01)

CPC (invention and additional information)

C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01)

Citation (search report)

See references of WO 9928316A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9928316 A1 19990610; AU 1666199 A 19990616; CA 2310054 A1 19990610; EP 1034176 A1 20000913; GB 9725138 D0 19980128; JP 2001524551 A 20011204

INPADOC legal status


2001-05-09 [18W] WITHDRAWN

- Date of withdrawal: 20010223

2000-09-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000530

2000-09-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-09-13 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000530;LT PAYMENT 20000530;LV PAYMENT 20000530;MK PAYMENT 20000530;RO PAYMENT 20000530;SI PAYMENT 20000530