EP 1034176 A1 20000913 - THIOPHENE-SULFONAMIDE COMPOUNDS
Title (en)
THIOPHENE-SULFONAMIDE COMPOUNDS
Title (de)
THIOPHENSULFONAMIDE DERIVATE
Title (fr)
COMPOSES THIOPHENE-SULFAMIDES
Publication
Application
Priority
- EP 9806993 W 19981027
- GB 9725138 A 19971127
Abstract (en)
[origin: WO9928316A1] Compounds of formula (I) wherein X is O or S; each of R, R1, and R2, which are the same or different, is independently hydrogen, halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino, C1-C6 alkoxy-carbonyl, or an unsaturated pentatomic heteromonocyclic ring containing one to three heteroatoms chosen independently from oxygen, sulphur and nitrogen, wherein the heteromonocyclic ring is unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; R3 is hydrogen, C1-C6 alkyl or a phenyl or benzyl group, in which the phenyl ring or phenyl moiety is unsubstitutedor substituted by one or two substituents chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino and C1-C6 alkoxy-carbonyl; each of R4 and R5, which are the same or different, is independently hydrogen or a phenyl ring unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; or R4 and R5 taken together form a C6-C14 aromatic ring system unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; and the pharmaceutically acceptable salts thereof have kynurenine-3-hydroxylase enzyme inhibitory activity.
IPC 1-7
C07D 413/14; C07D 417/14; C07D 413/12; C07D 417/12; A61K 31/42; A61K 31/425
IPC 8 full level
A61K 31/422 (2006.01); A61K 31/423 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01)
Citation (search report)
See references of WO 9928316A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9928316 A1 19990610; AU 1666199 A 19990616; CA 2310054 A1 19990610; EP 1034176 A1 20000913; GB 9725138 D0 19980128; JP 2001524551 A 20011204
DOCDB simple family (application)
EP 9806993 W 19981027; AU 1666199 A 19981027; CA 2310054 A 19981027; EP 98961128 A 19981027; GB 9725138 A 19971127; JP 2000523208 A 19981027