EP 1034290 A4 20040915 - FLAVIVIRUS EXPRESSION AND DELIVERY SYSTEM
Title (en)
FLAVIVIRUS EXPRESSION AND DELIVERY SYSTEM
Title (de)
FLAVIVIRUS EXPRESSIONS- UND VERABREICHUNGSSYSTEM
Title (fr)
SYSTEME D'EXPRESSION ET DE DIFFUSION PROPRE AU FLAVIVIRUS
Publication
Application
Priority
- AU 9800993 W 19981130
- AU PP062797 A 19971128
- AU PP609698 A 19980923
Abstract (en)
[origin: WO9928487A1] The present invention provides a gene expression system comprising: a) a self-replicating expression vector of flavivirus origin which includes the flavivirus 5' untranslated region (UTR), at least a portion of the 5' coding region for flavivirus core protein, the nucleotide sequence coding for the flavivirus non-structural proteins, and the complete or most of the 3'-terminal sequence of the flavivirus 3'UTR, required for self-replication of flavivirus genomic material, which vector is adapted to receive at least a nucleotide sequence without disrupting its replication capabilities; and b) at least a second vector that is capable of expressing flavivirus structural protein(s) and any other proteins required for packaging of the self-replicating expression vector into flavivirus viral particles which vector is engineered to prevent recombination with the self-replicating vector when in its presence.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12N 15/86 (2006.01); C12R 1/92 (2006.01)
CPC (source: EP)
C12N 15/86 (2013.01); C12N 2770/24143 (2013.01); C12N 2830/60 (2013.01); C12N 2830/85 (2013.01); C12N 2840/203 (2013.01)
Citation (search report)
- [XY] FROLOV ILYA ET AL: "Sindbis virus replicons and Sindbis virus: Assembly of chimeras and of particles deficient in virus RNA", JOURNAL OF VIROLOGY, vol. 71, no. 4, April 1997 (1997-04-01), pages 2819 - 2829, XP002289356, ISSN: 0022-538X
- [Y] KHROMYKH A A ET AL: "SUBGENOMIC REPLICONS OF THE FLAVIVIRUS KUNJIN: CONSTRUCTION AND APPLICATIONS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 2, February 1997 (1997-02-01), pages 1497 - 1505, XP000938940, ISSN: 0022-538X
- [Y] FROLOVA ELENA ET AL: "Packaging signals in alphaviruses", JOURNAL OF VIROLOGY, vol. 71, no. 1, January 1997 (1997-01-01), pages 248 - 258, XP002289429, ISSN: 0022-538X
- See references of WO 9928487A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9928487 A1 19990610; CA 2311395 A1 19990610; CA 2311395 C 20061128; EP 1034290 A1 20000913; EP 1034290 A4 20040915; JP 2002500003 A 20020108; JP 2008113666 A 20080522; NZ 504725 A 20030228
DOCDB simple family (application)
AU 9800993 W 19981130; CA 2311395 A 19981130; EP 98959672 A 19981130; JP 2000523363 A 19981130; JP 2007329155 A 20071220; NZ 50472598 A 19981130