Global Patent Index - EP 1034308 A1

EP 1034308 A1 2000-09-13 - METHOD OF GENERATING CONDITIONALLY EXPRESSED MUTANT CELLS USING EXPRESSIBLE ANTISENSE SEQUENCES

Title (en)

METHOD OF GENERATING CONDITIONALLY EXPRESSED MUTANT CELLS USING EXPRESSIBLE ANTISENSE SEQUENCES

Title (de)

VERFAHREN ZUR HERSTELLUNG CONDITIONELL EXPRIMIERTEN MUTANTEN ZELLEN MIT HILFE VON EXPRIEMIRTEN ANTISENSE SEQUENZEN

Title (fr)

PROCEDE METTANT EN OEUVRE DES SEQUENCES ANTISENS D'EXPRESSION POUR PRODUIRE DES CELLULES MUTANTES EXPRIMEES DE MANIERE CONDITIONNELLE

Publication

EP 1034308 A1 (EN)

Application

EP 98962914 A

Priority

  • US 9825808 W
  • US 6744697 P
  • US 8253498 P
  • US 10516198 P

Abstract (en)

[origin: WO9928508A1] The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a prometer that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compostions designed to target genes identified by this method are provided.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; C07H 21/02; C07H 21/04; C12N 15/64; C12N 15/74; C12N 15/75; C12N 15/76; C12N 15/77; C12N 15/78; C12N 15/79; C12N 15/81; C12N 15/85

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A01K 67/027 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12N 15/1079 (2013.01); A01K 67/027 (2013.01); C12Q 1/6897 (2013.01)

Designated contracting state (EPC)

BE CH DE DK FR GB IT LI NL

EPO simple patent family

WO 9928508 A1 19990610; EP 1034308 A1 20000913; EP 1034308 A4 20020403; JP 2002503447 A 20020205

INPADOC legal status


2005-09-14 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20050308

2004-12-15 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20041028

2002-04-03 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20020215

2002-04-03 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): BE CH DE DK FR GB IT LI NL

2002-03-20 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 12Q 1/68 A, 7C 12N 15/64 B, 7C 12N 15/74 B, 7C 12N 15/75 B, 7C 12N 15/76 B, 7C 12N 15/77 B, 7C 12N 15/78 B, 7C 12N 15/79 B, 7C 12N 15/81 B, 7C 12N 15/85 B, 7A 01K 67/027 B

2000-09-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000519

2000-09-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): BE CH DE DK FR GB IT LI NL