EP 1036069 A1 20000920 - BENZENESULFONAMIDE COMPOUNDS
Title (en)
BENZENESULFONAMIDE COMPOUNDS
Title (de)
BENZOLSUFONAMIDVERBINDUNGEN
Title (fr)
COMPOSES BENZENESULFAMIDES
Publication
Application
Priority
- EP 9806994 W 19981027
- GB 9725141 A 19971127
Abstract (en)
[origin: WO9928306A1] Compounds of formula (I) wherein X is O or S; at least one of R, R1, R2, R3, and R4, which are the same or different, is an unsaturated pentatomic heteromonocyclic ring containing one to three heteroatoms chosen independently from oxygen, sulphur and nitrogen, wherein the heteromonocyclic ring is unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl or two adjacents of R-R4 taken together form a benzene ring; and the remaining ones are hydrogen; R5 is hydrogen, C1-C6 alkyl, a benzyl or a phenyl group in which the phenyl moiety or the phenyl ring is unsubstituted or substituted by one or two substituents chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino and C1-C6 alkoxy-carbonyl; each of R6 and R7, which are the same or different, is independently hydrogen or a phenyl ring unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; or R6 and R7 taken together form a C6-C14 aromatic ring system unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl and the pharmaceutically acceptable salts thereof have kynurenine-3-hydroxylase enzyme inhibitory activity.
IPC 1-7
C07D 263/64; A61K 31/42; C07D 413/12; C07D 417/12; C07D 277/52
IPC 8 full level
A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/422 (2006.01); A61K 31/423 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 263/50 (2006.01); C07D 263/58 (2006.01); C07D 277/20 (2006.01); C07D 277/52 (2006.01); C07D 277/82 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP)
A61K 31/42 (2013.01); A61P 25/00 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07D 263/50 (2013.01); C07D 263/58 (2013.01); C07D 277/52 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01)
Citation (search report)
See references of WO 9928306A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9928306 A1 19990610; AU 1753599 A 19990616; CA 2309969 A1 19990610; EP 1036069 A1 20000920; GB 9725141 D0 19980128; JP 2001524546 A 20011204
DOCDB simple family (application)
EP 9806994 W 19981027; AU 1753599 A 19981027; CA 2309969 A 19981027; EP 98962319 A 19981027; GB 9725141 A 19971127; JP 2000523200 A 19981027