Global patent index - EP 1036069 A1

EP 1036069 A1 2000-09-20 - BENZENESULFONAMIDE COMPOUNDS

Title (en)

BENZENESULFONAMIDE COMPOUNDS

Title (de)

BENZOLSUFONAMIDVERBINDUNGEN

Title (fr)

COMPOSES BENZENESULFAMIDES

Publication

EP 1036069 A1 (EN)

Application

EP 98962319 A

Priority

  • EP 9806994 W
  • GB 9725141 A

Abstract (en)

[origin: WO9928306A1] Compounds of formula (I) wherein X is O or S; at least one of R, R1, R2, R3, and R4, which are the same or different, is an unsaturated pentatomic heteromonocyclic ring containing one to three heteroatoms chosen independently from oxygen, sulphur and nitrogen, wherein the heteromonocyclic ring is unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl or two adjacents of R-R4 taken together form a benzene ring; and the remaining ones are hydrogen; R5 is hydrogen, C1-C6 alkyl, a benzyl or a phenyl group in which the phenyl moiety or the phenyl ring is unsubstituted or substituted by one or two substituents chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino and C1-C6 alkoxy-carbonyl; each of R6 and R7, which are the same or different, is independently hydrogen or a phenyl ring unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; or R6 and R7 taken together form a C6-C14 aromatic ring system unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl and the pharmaceutically acceptable salts thereof have kynurenine-3-hydroxylase enzyme inhibitory activity.

IPC 1-7 (main, further and additional classification)

C07D 263/64; A61K 31/42; C07D 277/52; C07D 413/12; C07D 417/12

IPC 8 full level (invention and additional information)

C07D 277/20 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/422 (2006.01); A61K 31/423 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 263/50 (2006.01); C07D 263/58 (2006.01); C07D 277/52 (2006.01); C07D 277/82 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01)

CPC (invention and additional information)

C07D 263/58 (2013.01); A61K 31/42 (2013.01); C07D 263/50 (2013.01); C07D 277/52 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01)

Citation (search report)

See references of WO 9928306A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9928306 A1 19990610; AU 1753599 A 19990616; CA 2309969 A1 19990610; EP 1036069 A1 20000920; GB 9725141 D0 19980128; JP 2001524546 A 20011204

INPADOC legal status

2001-05-09 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20010223

2000-09-20 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000530

2000-09-20 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-09-20 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000530;LT PAYMENT 20000530;LV PAYMENT 20000530;MK PAYMENT 20000530;RO PAYMENT 20000530;SI PAYMENT 20000530