Global Patent Index - EP 1036165 A4

EP 1036165 A4 20030514 - HUMAN RNASE H AND COMPOSITIONS AND USES THEREOF

Title (en)

HUMAN RNASE H AND COMPOSITIONS AND USES THEREOF

Title (de)

MENSCHLICHE RNASE-H UND ZUSAMMENSETZUNGEN UND VERWENDUNGEN DAVON

Title (fr)

RNASE HUMAINE, COMPOSITIONS ET LEURS UTILISATIONS

Publication

EP 1036165 A4 20030514 (EN)

Application

EP 98961851 A 19981202

Priority

  • US 9825488 W 19981202
  • US 6745897 P 19971204

Abstract (en)

[origin: WO9928447A1] The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.

IPC 1-7

C12N 9/22; C12N 15/52; C12N 15/62; C12N 15/63; C12Q 1/68; C07H 21/04; C07K 16/40

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/7088 (2006.01); A61K 48/00 (2006.01); C07K 16/40 (2006.01); C12N 9/22 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP US)

C12N 9/22 (2013.01 - EP US); C12N 15/113 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C12N 2310/11 (2013.01 - EP US)

Citation (search report)

  • [XP] CERRITELLI S M ET AL: "CLONING, EXPRESSION AND MAPPING OF RIBONUCLEASES H OF HUMAN AND MOUSE RELATED TO BACTERIAL RNASE HI", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 53, 1998, pages 300 - 307, XP002951226, ISSN: 0888-7543
  • [T] WU HONGJIANG ET AL: "Properties of cloned and expressed human RNase H1.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 40, 1 October 1999 (1999-10-01), pages 28270 - 28278, XP002234691, ISSN: 0021-9258
  • [AP] WU HONGJIANG ET AL: "Identification and partial purification of human double strand RNase activity. A novel terminating mechanism for oligoribonucleotide antisense drugs.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 5, 30 January 1998 (1998-01-30), pages 2532 - 2542, XP002234692, ISSN: 0021-9258
  • See references of WO 9928447A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9928447 A1 19990610; AU 1707099 A 19990616; CA 2312002 A1 19990610; EP 1036165 A1 20000920; EP 1036165 A4 20030514; JP 2001525166 A 20011211; US 2002076712 A1 20020620; US 2002110892 A1 20020815; US 6001653 A 19991214; US 6001653 C1 20011016; US 6376661 B1 20020423

DOCDB simple family (application)

US 9825488 W 19981202; AU 1707099 A 19981202; CA 2312002 A 19981202; EP 98961851 A 19981202; JP 2000523324 A 19981202; US 20371698 A 19981202; US 5431301 A 20011022; US 68425400 A 20001006; US 86120501 A 20010518