EP 1037533 A1 20000927 - METHODS FOR THE USE OF INHIBITORS OF CO-REPRESSORS FOR THE TREATMENT OF NEOPLASTIC DISEASES
Title (en)
METHODS FOR THE USE OF INHIBITORS OF CO-REPRESSORS FOR THE TREATMENT OF NEOPLASTIC DISEASES
Title (de)
VERFAHREN ZUR VERWENDUNG VON INHIBITOREN VON CO-REPRESSOREN ZUR BEHANDLUNG NEOPLASTISCHER ERKRANKUNGEN
Title (fr)
METHODES D'UTILISATION D'INHIBITEURS DE CO-REPRESSEURS DANS LE CADRE DU TRAITEMENT DE MALADIES NEOPLASIQUES
Publication
Application
Priority
- US 9823962 W 19981110
- US 96687697 A 19971110
Abstract (en)
[origin: WO9923885A1] The present invention is related to the use of histone deacetylase inhibitors as activators of genes responsive to hormone receptors and to counteract the oncogenic functions of oncogenic proteins. Histone deacetylase relieves repressed systems and, when in combination with a ligand for a member of the steroid/thyroid hormone superfamily, the differentiation effects of retinoids are enhanced. Formulations for modulating hormone-mediated processes and assays for the identification of potential modulators are presented.
IPC 1-7
A01N 47/40; C07K 1/00; C07K 16/00; C07J 1/00; G01N 33/567; C12N 9/99; C12N 9/14; C12N 9/18
IPC 8 full level
C07K 14/47 (2006.01)
CPC (source: EP)
C07K 14/4703 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 9923885A1
Designated contracting state (EPC)
CH DE FR GB LI
DOCDB simple family (publication)
WO 9923885 A1 19990520; AU 1395999 A 19990531; CA 2308377 A1 19990520; EP 1037533 A1 20000927
DOCDB simple family (application)
US 9823962 W 19981110; AU 1395999 A 19981110; CA 2308377 A 19981110; EP 98957781 A 19981110