Global Patent Index - EP 1037533 A1

EP 1037533 A1 2000-09-27 - METHODS FOR THE USE OF INHIBITORS OF CO-REPRESSORS FOR THE TREATMENT OF NEOPLASTIC DISEASES

Title (en)

METHODS FOR THE USE OF INHIBITORS OF CO-REPRESSORS FOR THE TREATMENT OF NEOPLASTIC DISEASES

Title (de)

VERFAHREN ZUR VERWENDUNG VON INHIBITOREN VON CO-REPRESSOREN ZUR BEHANDLUNG NEOPLASTISCHER ERKRANKUNGEN

Title (fr)

METHODES D'UTILISATION D'INHIBITEURS DE CO-REPRESSEURS DANS LE CADRE DU TRAITEMENT DE MALADIES NEOPLASIQUES

Publication

EP 1037533 A1 (EN)

Application

EP 98957781 A

Priority

  • US 9823962 W
  • US 96687697 A

Abstract (en)

[origin: WO9923885A1] The present invention is related to the use of histone deacetylase inhibitors as activators of genes responsive to hormone receptors and to counteract the oncogenic functions of oncogenic proteins. Histone deacetylase relieves repressed systems and, when in combination with a ligand for a member of the steroid/thyroid hormone superfamily, the differentiation effects of retinoids are enhanced. Formulations for modulating hormone-mediated processes and assays for the identification of potential modulators are presented.

IPC 1-7 (main, further and additional classification)

A01N 47/40; C07J 1/00; C07K 1/00; C07K 16/00; C12N 9/14; C12N 9/18; C12N 9/99; G01N 33/567

IPC 8 full level (invention and additional information)

C07K 14/47 (2006.01)

CPC (invention and additional information)

C07K 14/4703 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9923885A1

Designated contracting state (EPC)

CH DE FR GB LI

EPO simple patent family

WO 9923885 A1 19990520; AU 1395999 A 19990531; CA 2308377 A1 19990520; EP 1037533 A1 20000927

INPADOC legal status


2001-02-28 [18W] WITHDRAWN

- Date of withdrawal: 20001228

2000-09-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000609

2000-09-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): CH DE FR GB LI