Global Patent Index - EP 1037610 A4

EP 1037610 A4 20040707 - LIPOSOMAL CAMPTOTHECIN FORMULATIONS

Title (en)

LIPOSOMAL CAMPTOTHECIN FORMULATIONS

Title (de)

LIPOSOMALE CAMPTOTHECIN FORMULIERUNGEN

Title (fr)

COMPOSITIONS A BASE DE LIPOSOMES RENFERMANT DE LA CAMPTOTHECINE

Publication

EP 1037610 A4 20040707 (EN)

Application

EP 98946983 A 19980915

Priority

  • US 9819086 W 19980915
  • US 5908397 P 19970916

Abstract (en)

[origin: WO9913816A2] Liposomal encapsulated camptothecin formulations are provided. The liposomes have improved pharmacokinetics, enhanced efficacy as anti-tumor agents and provide an increased therapeutic index as compared to the free drug and topotecan. The formulations include liposomes comprising at least one phospholipid and a camptothecin or analog thereof.

IPC 1-7

A61K 9/127; A61K 31/4745

IPC 8 full level

A61K 9/127 (2006.01); A61K 31/4745 (2006.01); A61K 31/496 (2006.01); A61K 47/04 (2006.01); A61K 47/12 (2006.01); A61K 47/16 (2006.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP KR)

A61K 9/127 (2013.01 - EP KR); A61K 9/1278 (2013.01 - EP); A61K 31/4745 (2013.01 - EP); A61K 31/496 (2013.01 - EP); A61P 31/12 (2017.12 - EP); A61P 35/00 (2017.12 - EP)

Citation (search report)

  • [XY] WO 9508986 A1 19950406 - SMITHKLINE BEECHAM CORP [US], et al
  • [Y] CULLIS PR, MAYER LD, BALLY MB, MADDEN TD, HOPE MJ: "Generating and loading of liposomal systems for drug-delivery applications", ADVANCED DRUG DELIVERY REVIEWS, vol. 3, 1989, pages 267 - 282, XP002279310
  • [XA] DAOUD S S ET AL: "ANTITUMOR EFFECT OF LIPOSOME-INCORPORATED CAMPTOTHECIN IN HUMAN MALIGNANT XENOGRAFTS", ANTI-CANCER DRUGS, RAPID COMMUNICATIONS, OXFORD, GB, vol. 6, no. 1, 1995, pages 83 - 93, XP000878680, ISSN: 0959-4973
  • [A] BURKE T G ET AL: "STABILIZATION OF TOPOTECAN IN LOW PH LIPOSOMES COMPOSED OF DISTEAROYLPHOSPHATIDYLCHOLINE", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 83, no. 7, 1 July 1994 (1994-07-01), pages 967 - 969, XP000454801, ISSN: 0022-3549
  • [A] SUGARMAN S ET AL: "LIPOSOMAL CAMPTOTHECIN: FORMULATION AND CYTOTOXICITY AGAINST KB CELLS", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. ORLANDO, MAY 19 - 22, 1993, PHILADELPHIA, AACR, US, vol. MEETING 84, 1 March 1993 (1993-03-01), pages 422, XP000578376, ISSN: 0197-016X
  • See references of WO 9913816A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9913816 A2 19990325; WO 9913816 A3 20011101; AU 751439 B2 20020815; AU 9387798 A 19990405; BR 9812316 A 20010320; CA 2303366 A1 19990325; EP 1037610 A1 20000927; EP 1037610 A4 20040707; JP 2003510239 A 20030318; KR 100711315 B1 20070427; KR 20010030599 A 20010416; NZ 503293 A 20020927

DOCDB simple family (application)

US 9819086 W 19980915; AU 9387798 A 19980915; BR 9812316 A 19980915; CA 2303366 A 19980915; EP 98946983 A 19980915; JP 2000511445 A 19980915; KR 20007002701 A 20000315; NZ 50329398 A 19980915