Global Patent Index - EP 1037628 A1

EP 1037628 A1 2000-09-27 - METHODS FOR PREVENTING RESTENOSIS USING TOCOTRIENOLS

Title (en)

METHODS FOR PREVENTING RESTENOSIS USING TOCOTRIENOLS

Title (de)

VERFAHREN ZUR VORBEUGUNG VON RESTENOSE UNTER VERWENDUNG VON TOCOTRIENOLE

Title (fr)

METHODES DE PREVENTION DE LA RESTENOSE UTILISANT DES TOCOTRIENOLS

Publication

EP 1037628 A1 (EN)

Application

EP 98960259 A

Priority

  • US 9824606 W
  • US 97170397 A

Abstract (en)

[origin: WO9925336A1] This invention relates to the prevention of restenosis using tocotrienols. Specifically, this invention relates to the use of individual tocotrienols (such as P25 tocotrienol), mixtures of tocotrienols and mixtures of one or more tocotrienols with other substances (such as the TRF25 mixture). The methods of this invention include a method for administering a pharmaceutically acceptable composition comprising a tocotrienol to a patient in need of restenosis prophylaxis and a method for preventing restenosis in a patient undergoing an arterial angioplastic procedure comprising the steps of: (a) coating the exterior surface of an angioplastic balloon with a composition comprising a tocotrienol; and (b) performing the arterial angioplastic procedure such that a prophylactically effective amount of the composition is transferred to the interior surface of the artery.

IPC 1-7 (main, further and additional classification)

A61K 31/355; A61K 31/60

IPC 8 full level (invention and additional information)

C07D 311/22 (2006.01); A61F 2/06 (2006.01); A61K 31/352 (2006.01); A61K 31/353 (2006.01); A61K 31/355 (2006.01); A61K 31/60 (2006.01); A61P 9/00 (2006.01); C07D 311/58 (2006.01)

CPC (invention and additional information)

A61K 31/355 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9925336 A1 19990527; AU 1590299 A 19990607; AU 746369 B2 20020418; CA 2310232 A1 19990527; EP 1037628 A1 20000927; EP 1037628 A4 20020821; ID 26335 A 20001214; JP 2001522880 A 20011120

INPADOC legal status


2003-12-03 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030531

2002-08-21 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20020709

2002-08-21 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-09-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000616

2000-09-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE