Global Patent Index - EP 1037628 A4

EP 1037628 A4 20020821 - METHODS FOR PREVENTING RESTENOSIS USING TOCOTRIENOLS

Title (en)

METHODS FOR PREVENTING RESTENOSIS USING TOCOTRIENOLS

Title (de)

VERFAHREN ZUR VORBEUGUNG VON RESTENOSE UNTER VERWENDUNG VON TOCOTRIENOLE

Title (fr)

METHODES DE PREVENTION DE LA RESTENOSE UTILISANT DES TOCOTRIENOLS

Publication

EP 1037628 A4 20020821 (EN)

Application

EP 98960259 A 19981117

Priority

  • US 9824606 W 19981117
  • US 97170397 A 19971117

Abstract (en)

[origin: WO9925336A1] This invention relates to the prevention of restenosis using tocotrienols. Specifically, this invention relates to the use of individual tocotrienols (such as P25 tocotrienol), mixtures of tocotrienols and mixtures of one or more tocotrienols with other substances (such as the TRF25 mixture). The methods of this invention include a method for administering a pharmaceutically acceptable composition comprising a tocotrienol to a patient in need of restenosis prophylaxis and a method for preventing restenosis in a patient undergoing an arterial angioplastic procedure comprising the steps of: (a) coating the exterior surface of an angioplastic balloon with a composition comprising a tocotrienol; and (b) performing the arterial angioplastic procedure such that a prophylactically effective amount of the composition is transferred to the interior surface of the artery.

IPC 1-7

A61K 31/355; A61K 31/60

IPC 8 full level

A61F 2/06 (2013.01); A61K 31/352 (2006.01); A61K 31/353 (2006.01); A61K 31/355 (2006.01); A61K 31/60 (2006.01); A61P 9/00 (2006.01); C07D 311/22 (2006.01); C07D 311/58 (2006.01)

CPC (source: EP)

A61K 31/355 (2013.01); A61P 9/00 (2017.12)

Citation (search report)

  • [XDY] US 5591772 A 19970107 - LANE RONALD H [US], et al
  • [Y] EP 0669132 A1 19950830 - KRAAIJ ANTONIUS MARINUS MARIA [NL], et al
  • [Y] DE 4333794 A1 19950406 - WEISCHER CARL HEINRICH DR [DE], et al
  • [XY] KARPEN C W ET AL: "TOCOTRIENOL-INDUCED INHIBITION OF PLATELET THROMBUS FORMATION AND PLATELET AGGREGATION IN A STENOSEL CORONARY ARTERY CANINE MODEL", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 4, PART 2, no. 90, 14 November 1994 (1994-11-14), pages 1181, XP008004384, ISSN: 0009-7322
  • [XY] TOMEO ET AL.: "Antioxidant effects of vitamin E and gamma-tocotrienol in hyperlipidemic subjects with carotid artery stenosis - A preliminary report", CLIN. RES., vol. 42, no. 1, - 1994, pages 29a, XP008004386
  • [XY] TOMEO A C ET AL: "ANTIOXIDANT EFFECTS OF PV IN HYPERLIPIDEMIC SUBJECTS WITH CAROTID ARTERY STENOSIS", CLINICAL RESEARCH, THOROFARE, NJ, US, vol. 2, no. 42, 29 April 1994 (1994-04-29), pages 158A, XP008004385, ISSN: 0009-9279
  • [XY] KOOYENGA D ET AL: "ANTIOXIDANT EFFECTS OF TOCOTRIENOLS IN PATIENTS WITH CAROTID STENOSIS", JOURNAL OF INVESTIGATIVE MEDICINE, AMERICAN FEDERATION FOR CLINICAL RESEARCH,, US, vol. 3, no. 44, 3 May 1996 (1996-05-03), pages 245A, XP008004383, ISSN: 1081-5589
  • [XY] PACKER L: "INTERACTIONS AMONG ANTIOXIDANTS IN HEALTH AND DISEASE: VITAMIN E AND ITS REDOX CYCLE", PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY & MEDICINE, ACADEMIC PRESS INC. NEW YORK, US, vol. 2, no. 200, June 1992 (1992-06-01), pages 271 - 276, XP001073940, ISSN: 0037-9727
  • [XY] AZZI A ET AL: "MODULATION OF CELL PROLIFERATION BY TOCOPHEROLS AND TOCOTRIENOLS: ROLE IN ARTERIOSCLEROSIS", LIPID SOLUBLE ANTIOXIDANTS: BIOCHEMISTRY AND CLINICAL APPLICATIONS, BIRKHAEUSER VERLAG, BASEL, CH, 1992, pages 123 - 133, XP008004536
  • [A] QURESHI A A ET AL: "NOVEL TOCOTRIENOLS OF RICE BRAN MODULATE CARDIOVASCULAR DISEASE RISK PARAMETERS OF HYPERCHOLESTEROLEMIC HUMANS", JOURNAL OF NUTRITIONAL BIOCHEMISTRY, BUTTERWORTH PUBLISHERS, STONEHAM, GB, vol. 8, no. 5, May 1997 (1997-05-01), pages 290 - 298, XP001026694, ISSN: 0955-2863
  • [A] GELLER M R ET AL: "Palmvitee-induced carotid plaque regression in humans.", STROKE (26, NO. 1, 162, 1995) CODEN: SJCCA7 ISSN: 0039-2499, XP008004540
  • See references of WO 9925336A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9925336 A1 19990527; AU 1590299 A 19990607; AU 746369 B2 20020418; CA 2310232 A1 19990527; EP 1037628 A1 20000927; EP 1037628 A4 20020821; ID 26335 A 20001214; JP 2001522880 A 20011120

DOCDB simple family (application)

US 9824606 W 19981117; AU 1590299 A 19981117; CA 2310232 A 19981117; EP 98960259 A 19981117; ID 20001179 A 19981117; JP 2000520770 A 19981117