EP 1037668 A1 20000927 - TRANSFECTION PARTICLES
Title (en)
TRANSFECTION PARTICLES
Title (de)
TRANSFEKTION PARTIKELN
Title (fr)
PARTICULES DE TRANSFECTION
Publication
Application
Priority
- EP 98962400 A 19981128
- EP 9807695 W 19981128
- EP 97121308 A 19971204
Abstract (en)
[origin: WO9929349A1] Transfection particles for delivery of nucleic acid into higher eucaryotic cells in vitro and in vivo comprises one or more nucleic acid molecules condensed by organic cationic molecules. The discrete and stable particles are obtained by complexing the nucleic acid molecules with identical or different organic cartionic precursor molecules without crosslinking nucleic acid molecules, and covalently linking the precursor molecules to each other on the nucleic acid template. For specific cellular targeting, the particles may carry targeting molecules, e.g. sugars. Preferred cationic precursor molecules are lipophilic detergents that are linked to form lipids. The particles contain preferably only one nucleic acid molecule which makes them useful for gene therapy and for delivery of large DNA molecules.
IPC 1-7
IPC 8 full level
A61K 35/76 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP KR)
A61K 47/50 (2017.08 - KR); A61K 47/543 (2017.08 - EP); A61K 47/6929 (2017.08 - EP); B82Y 5/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9929349 A1 19990617; AR 014054 A1 20010131; AU 1757799 A 19990628; BR 9814255 A 20001010; CA 2312890 A1 19990617; CN 1290178 A 20010404; EE 200000797 A 20020617; EP 0945138 A1 19990929; EP 1037668 A1 20000927; HU P0004322 A2 20010228; HU P0004322 A3 20030428; IL 136418 A0 20010614; JP 2001525378 A 20011211; KR 20010032775 A 20010425; NO 20002793 D0 20000531; NO 20002793 L 20000801; PL 345849 A1 20020114; SK 8222000 A3 20001211; TR 200001597 T2 20020321; UY 25286 A1 20010131; ZA 9811011 B 19990604
DOCDB simple family (application)
EP 9807695 W 19981128; AR P980106157 A 19981204; AU 1757799 A 19981128; BR 9814255 A 19981128; CA 2312890 A 19981128; CN 98813498 A 19981128; EE P200000797 A 19981128; EP 97121308 A 19971204; EP 98962400 A 19981128; HU P0004322 A 19981128; IL 13641898 A 19981128; JP 2000524018 A 19981128; KR 20007006071 A 20000602; NO 20002793 A 20000531; PL 34584998 A 19981128; SK 8222000 A 19981128; TR 200001597 T 19981128; UY 25286 A 19981204; ZA 9811011 A 19981202