Global Patent Index - EP 1037672 A1

EP 1037672 A1 2000-09-27 - DENDRITIC POLYMER-SACCHARIDE CONJUGATE, PHARMACEUTICALS CONTAINING SAID CONJUGATE, METHOD FOR ITS PRODUCTION AND USE THEREOF

Title (en)

DENDRITIC POLYMER-SACCHARIDE CONJUGATE, PHARMACEUTICALS CONTAINING SAID CONJUGATE, METHOD FOR ITS PRODUCTION AND USE THEREOF

Title (de)

DENDRITISCHE POLYMER-SACCHARID-KONJUGATE, DIESE ENTHALTENDE PHARMAZEUTISCHE MITTEL, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG

Title (fr)

CONJUGUES POLYMERES DENDRITIQUES-SACCHARIDES, PRODUITS PHARMACEUTIQUES CONTENANT CES CONJUGUES, LEUR PROCEDE DE PRODUCTION ET LEUR UTILISATION

Publication

EP 1037672 A1 (DE)

Application

EP 98966256 A

Priority

  • DE 19758105 A
  • EP 9807927 W

Abstract (en)

[origin: DE19758105A1] Dendritic polymer-saccharide conjugates comprising an amino-substituted dendritic polymer with branching derived from vinyl cyanide units, a signal emitting group containing metal ion(s), mono- or oligosaccharides and optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are new. Conjugates comprising: (a) an amino-substituted dendritic polymer in which the branching is derived from vinyl cyanide units; (b) a signal emitting group containing metal ion(s); (c) mono- or oligosaccharides; and optionally (d) cations of inorganic and/or organic bases, amino acids or amino acid amides. Preferred conjugates have formula (I): P = dendritic polymer with branching derived from vinyl cyanide units and containing k amino groups of which (n+m) are each devoid of one H and k is equal to or greater than (n+m); n and m = 1-149; k = 12-150; K = signal emitting group containing metal ion(s); L = linker; and Z = mono- or oligosaccharide devoid of one OH. An Independent claim is also included for the preparation of conjugates (I) in which K is a group of formula (II)-(VI): R1 = H or metal ion of element with atomic number 20-32, 37-39, 42-44, 49 or 57-83, but at least two R1's are other than H; R2 = H, 1-7C alkyl, phenyl or benzyl; V = a group -OCH2(CH2)o(O)p(p-benzylene)l-; o = 0-10; p and l = 0 or 1, but p is only 1 when l is 1; T1 = -NHCS- or -CO-; U = -CHR3-CONR3-M1- or -CH2-CH(OH)-M2-; R3 = R2 or -CH2-(CH2)o-COOH; and M1 and M2 = phenylene or saturated or unsaturated 1-20C alkylene optionally mono- to penta-substituted with (CH2)o-COOH or OR2 or optionally containing 1-8 O atoms, 1 or 2 -NH-, -C(NH)-, phenylene or phenyleneoxy units or 1-5 -CONR3- or -NR3CO- units.

IPC 1-7 (main, further and additional classification)

A61K 49/00

IPC 8 full level (invention and additional information)

A61K 49/08 (2006.01); C08G 83/00 (2006.01)

CPC (invention and additional information)

C08G 83/003 (2013.01); A61K 49/085 (2013.01); A61K 49/124 (2013.01); A61K 2039/5154 (2013.01)

Citation (search report)

See references of WO 9932154A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19758105 A1 19990624; AU 2268099 A 19990712; EP 1037672 A1 20000927; WO 9932154 A1 19990701

INPADOC legal status


2001-06-13 [18W] WITHDRAWN

- Date of withdrawal: 20010410

2000-09-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000422

2000-09-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE