EP 1037910 A2 20000927 - MAINTENANCE OF SMOOTH MUSCLE INTEGRITY BY MORPHOGENIC PROTEINS
Title (en)
MAINTENANCE OF SMOOTH MUSCLE INTEGRITY BY MORPHOGENIC PROTEINS
Title (de)
NACHSCHUTZ DER GLATTE MUSKULATUR DURCH MORPHOGENETISCHE PROTEIN
Title (fr)
ENTRETIEN DE L'INTEGRITE DE MUSCLES LISSES A L'AIDE DE PROTEINES MORPHOGENIQUES
Publication
Application
Priority
- US 9825398 W 19981130
- US 6769097 P 19971204
Abstract (en)
[origin: WO9928341A2] Disclosed are compositions and methods for maintaining the integrity of smooth muscle, particularly vascular smooth muscle. Vascular diseases are characterized by an excessive build-up of vascular smooth muscle cells, resulting in an occlusion of a blood vessel, and/or by loss of elasticity in the blood vessels. Causes of blood vessel occlusion include smooth muscle cell proliferation and inflammatory responses. Inhibition of the proliferation of smooth muscle cells or inflammatory responses represents an effective treatment for vascular disorders, such as atherosclerosis and restenosis. Treatment may include administration of a morphogenic protein. The protein itself may be delivered to the site of vascular occlusion or the protein may be delivered by a vector, such as an adenoviral vector containing a DNA insert encoding a morphogenic protein. Such compositions and methods may also inhibit the responses of smooth muscle cells to various traumas, such as exposure to toxic agents. All of these treatmetns operate to preserve the cell phenotype by inhibiting an increase in extracellular matrix proteins, such as collagen, or by maintaining the normal balance of extracellular matrix proteins, such as Types I and III collagen.
IPC 1-7
IPC 8 full level
A61K 38/18 (2006.01); C07K 14/47 (2006.01); C07K 14/51 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61K 38/1875 (2013.01); C07K 14/4702 (2013.01); C07K 14/51 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
See references of WO 9928341A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9928341 A2 19990610; WO 9928341 A3 19990805; WO 9928341 A9 20010531; AU 1706499 A 19990616; CA 2314423 A1 19990610; EP 1037910 A2 20000927
DOCDB simple family (application)
US 9825398 W 19981130; AU 1706499 A 19981130; CA 2314423 A 19981130; EP 98961838 A 19981130