EP 1037919 A1 20000927 - PROTEINS FOR CANCER CELL SPECIFIC INDUCTION OF APOPTOSIS AND METHOD FOR ISOLATION THEREOF
Title (en)
PROTEINS FOR CANCER CELL SPECIFIC INDUCTION OF APOPTOSIS AND METHOD FOR ISOLATION THEREOF
Title (de)
PROTEINE ZUR KREBSZELLSPEZIFISCHEN INDUKTION VON APOPTOSE UND VERFAHREN FÜR IHRE ISOLIERUNG
Title (fr)
PROTEINES DESTINEES A PROVOQUER L'APOPTOSE SPECIFIQUE DE CELLULES CANCEREUSES ET PROCEDE POUR ISOLER CES PROTEINES
Publication
Application
Priority
- US 9827108 W 19981218
- US 99343297 A 19971218
Abstract (en)
[origin: WO9931135A1] The present invention provides the methods to isolate the proteins specifically induced apoptosis (programmed cell death) in prostate cancer cells (LNCAP), leukemia cells (HL-60), and breast cancer cells (MCF-70), but without effect in normal human lung fibroblast cells (CCD 39 Lu). P-1 has no effect on breast cancer cells. Five proteins have been isolated from the conditioned media of culture cells: (1) Apogen P-1: the proteins (Apogen P-1a, Apogen P-1b and Apogen P-1c) isolated from the conditioned medium of XC cells are able to induce apoptosis in prostate cancer cells (LNCAP) without effect in normal human lung fibroblast (CCD 39 Lu), colon cancer (T84), breast cancer (MCF-7) and leukemia (HL-60) cells. (2) Apogen P-2: the protein isolated from the conditioned medium of C3H1OT1/2 cells is able to induce apoptosis in prostate cancer cells (LNCAP) and breast cancer (MCF-7) without effect in normal human lung fibroblast (CCD 39 Lu) and colon cancer (T84) cells. (3) Apogen L: the protein isolated from the conditioned medium of XC cells is able to induce apoptosis in leukemia cells (HL-60), and breast cancer (MCF-7) without effect in normal human lung fibroblast (CCD 39 Lu), colon cancer (T84) and prostate cancer (LNCAP) cells. The invention may lead to the discovery of a novel class of anticancer drug that aims at prostate cancer, breast cancer, leukemia and other cancers by inducing apoptosis in cancer cells without affecting normal cells.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/71 (2006.01)
CPC (source: EP KR)
A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/47 (2013.01 - KR); C07K 14/4747 (2013.01 - EP); C07K 14/71 (2013.01 - EP); A61K 38/00 (2013.01 - EP)
Citation (search report)
See references of WO 9931135A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9931135 A1 19990624; AU 1933099 A 19990705; CA 2325368 A1 19990624; CN 1314914 A 20010926; EP 1037919 A1 20000927; IL 136850 A0 20010614; JP 2002516821 A 20020611; KR 20010033260 A 20010425; MX PA00005954 A 20020918; NO 20003099 D0 20000616; NO 20003099 L 20000817; PL 343247 A1 20010730
DOCDB simple family (application)
US 9827108 W 19981218; AU 1933099 A 19981218; CA 2325368 A 19981218; CN 98813660 A 19981218; EP 98964142 A 19981218; IL 13685098 A 19981218; JP 2000539058 A 19981218; KR 20007006696 A 20000617; MX PA00005954 A 19981218; NO 20003099 A 20000616; PL 34324798 A 19981218