Global Patent Index - EP 1037963 A1

EP 1037963 A1 20000927 - X-RAY CRYSTAL COMPRISING HIV-1 GP120

Title (en)

X-RAY CRYSTAL COMPRISING HIV-1 GP120

Title (de)

RÖNTGENSTRAHLEN-KRISTALL, ENTHALTEND HIV-1 GP120

Title (fr)

RAYONS X CRISTAL COMPRENANT VIH-1 GP120

Publication

EP 1037963 A1 20000927 (EN)

Application

EP 98959406 A 19981110

Priority

  • US 9823905 W 19981110
  • US 96698797 A 19971110
  • US 96740397 A 19971110
  • US 96693297 A 19971110
  • US 96714897 A 19971110
  • US 97674197 A 19971124
  • US 10076398 A 19980618
  • US 10063198 A 19980618
  • US 10052998 A 19980618
  • US 10076298 A 19980618
  • US 10052198 A 19980618
  • US 8958098 P 19980617
  • US 8958198 P 19980617

Abstract (en)

[origin: WO9924553A2] The subject invention provides a crystal suitable for X-ray diffraction comprising a polypeptide having an amino acid sequence of a portion of a Human Immunodeficiency Virus envelope glycoprotein gp120. The subject invention also provides the above-described crystals, wherein the crystal is arranged in a space group P2221, so as to form a unit cell of dimensions a=71.6 ANGSTROM , b=88.1 ANGSTROM , c=196.7 ANGSTROM , and which effectively diffracts X-rays for determination of the atomic coordinates of the gp120 to a resolution of 2.5 ANGSTROM or better. The subject invention additionally provides compounds inhibiting the CD4-gp 120 interaction, compounds inhibiting chemokine receptor-gp120 interaction, mimics of CD4, gp120 variants and uses thereof.

IPC 1-7

C07K 14/16; C07K 14/73; C07K 16/08; A61K 38/00

IPC 8 full level

A61K 38/00 (2006.01); C07K 5/00 (2006.01); C07K 14/16 (2006.01); C07K 14/73 (2006.01); C07K 16/08 (2006.01); G01N 23/20 (2006.01); G01N 23/201 (2006.01); G01N 23/207 (2006.01)

IPC 8 main group level

C12N (2006.01)

CPC (source: EP US)

A61K 38/00 (2013.01 - EP US); C07K 5/00 (2013.01 - EP); C07K 14/005 (2013.01 - EP); C07K 16/08 (2013.01 - EP); C12N 1/00 (2013.01 - EP); G01N 23/20 (2013.01 - EP); G01N 23/207 (2013.01 - EP US); C12N 2740/16022 (2013.01 - EP)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9924553 A2 19990520; WO 9924553 A3 20031211; WO 9924553 A8 19990722; WO 9924553 A9 20010531; EP 1037963 A1 20000927; EP 1037963 A4 20040922

DOCDB simple family (application)

US 9823905 W 19981110; EP 98959406 A 19981110