EP 1037963 A4 20040922 - X-RAY CRYSTAL COMPRISING HIV-1 GP120
Title (en)
X-RAY CRYSTAL COMPRISING HIV-1 GP120
Title (de)
RÖNTGENSTRAHLEN-KRISTALL, ENTHALTEND HIV-1 GP120
Title (fr)
RAYONS X CRISTAL COMPRENANT VIH-1 GP120
Publication
Application
Priority
- US 9823905 W 19981110
- US 96698797 A 19971110
- US 96740397 A 19971110
- US 96693297 A 19971110
- US 96714897 A 19971110
- US 97674197 A 19971124
- US 10076398 A 19980618
- US 10063198 A 19980618
- US 10052998 A 19980618
- US 10076298 A 19980618
- US 10052198 A 19980618
- US 8958098 P 19980617
- US 8958198 P 19980617
Abstract (en)
[origin: WO9924553A2] The subject invention provides a crystal suitable for X-ray diffraction comprising a polypeptide having an amino acid sequence of a portion of a Human Immunodeficiency Virus envelope glycoprotein gp120. The subject invention also provides the above-described crystals, wherein the crystal is arranged in a space group P2221, so as to form a unit cell of dimensions a=71.6 ANGSTROM , b=88.1 ANGSTROM , c=196.7 ANGSTROM , and which effectively diffracts X-rays for determination of the atomic coordinates of the gp120 to a resolution of 2.5 ANGSTROM or better. The subject invention additionally provides compounds inhibiting the CD4-gp 120 interaction, compounds inhibiting chemokine receptor-gp120 interaction, mimics of CD4, gp120 variants and uses thereof.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); C07K 5/00 (2006.01); C07K 14/16 (2006.01); C07K 14/73 (2006.01); C07K 16/08 (2006.01); G01N 23/20 (2006.01); G01N 23/201 (2006.01); G01N 23/207 (2006.01)
IPC 8 main group level
C12N (2006.01)
CPC (source: EP US)
A61K 38/00 (2013.01 - EP US); C07K 5/00 (2013.01 - EP); C07K 14/005 (2013.01 - EP); C07K 16/08 (2013.01 - EP); C12N 1/00 (2013.01 - EP); G01N 23/20 (2013.01 - EP); G01N 23/207 (2013.01 - EP US); C12N 2740/16022 (2013.01 - EP)
Citation (search report)
- [X] RINI JAMES M ET AL: "Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 90, no. 13, 1993, 1993, pages 6325 - 6329, XP002276067, ISSN: 0027-8424
- [X] GHIARA J B ET AL: "Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 266, no. 1, 14 February 1997 (1997-02-14), pages 31 - 39, XP004462201, ISSN: 0022-2836
- [X] STURA E A ET AL: "CRYSTALLIZATION, SEQUENCE, AND PRELIMINARY CRYSTALLOGRAPHIC DATA FOR AN ANTIPEPTIDE FAB 50.1 AND PEPTIDE COMPLEXES WITH THE PRINCIPAL NEUTRALIZING DETERMINANT OF HIV-1 GP120", PROTEINS: STRUCTURE, FUNCTION AND GENETICS, ALAN R. LISS, US, vol. 14, no. 4, December 1992 (1992-12-01), pages 499 - 508, XP001069692, ISSN: 0887-3585
- [A] OXFORD J S ET AL: "New scientific developments towards an AIDS vaccine: report on a workshop organized by EU programme EVA entitled Novel approaches to AIDS vaccine development held at the Institut Pasteur, Paris", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 14, no. 17, 1 December 1996 (1996-12-01), pages 1712 - 1717, XP004016836, ISSN: 0264-410X
- [A] SANEJOUAND Y-H: "On the role of CD4 conformational change in the HIV-cell fusion process", COMPTES RENDUS DES SEANCES DE L'ACADEMIE DES SCIENCES. SERIE III: SCIENCES DE LA VIE, ELSEVIER, AMSTERDAM, NL, vol. 320, no. 2, February 1997 (1997-02-01), pages 163 - 170, XP004349275, ISSN: 0764-4469
- [XP] WYATT R ET AL: "THE ANTIGENIC STRUCTURE OF THE HIV gp120 ENVELOPE GLYCOPROTEIN", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 393, 18 June 1998 (1998-06-18), pages 705 - 711, XP002093503, ISSN: 0028-0836
- [XP] KWONG P D ET AL: "STRUCTURE OF AN HIV gp120 ENVELOPE GLYCOPROTEIN IN COMPLEX WITH THE CD4 RECEPTOR AND A NEUTRALIZING HUMAN ANTIBODY", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 393, 18 June 1998 (1998-06-18), pages 648 - 659, XP002093502, ISSN: 0028-0836
- See references of WO 9924553A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9924553 A2 19990520; WO 9924553 A3 20031211; WO 9924553 A8 19990722; WO 9924553 A9 20010531; EP 1037963 A1 20000927; EP 1037963 A4 20040922
DOCDB simple family (application)
US 9823905 W 19981110; EP 98959406 A 19981110