EP 1037983 A1 20000927 - MUTANTS OF ENDOSTATIN, "EM-1" HAVING ANTI-ANGIOGENIC ACTIVITY
Title (en)
MUTANTS OF ENDOSTATIN, "EM-1" HAVING ANTI-ANGIOGENIC ACTIVITY
Title (de)
MUTANTEN VON ENDOSTATIN, "EM 1" MIT ANTIANGIOGENER AKTIVITÄT UND VERFAHREN FÜR IHRE ANWENDUNG
Title (fr)
MUTANTS D'ENDOSTATINE "EM 1" PRESENTANT UNE ACTIVITE ANTI-ANGIOGENIQUE ET LEURS METHODES D'UTILISATION
Publication
Application
Priority
- US 9826057 W 19981208
- US 6788897 P 19971208
- US 8266398 P 19980422
- US 10853698 P 19981116
Abstract (en)
[origin: WO9929878A3] Methods for making proteins with anti-angiogenic properties are disclosed, including angiostatin, endostatin and restin. The system used is a yeast expression system which produces biologically active proteins at high titer, specifically the Pichia pastores yeast expression system.
IPC 1-7
C12N 15/12; C07K 14/78; C12Q 1/68; C12N 15/62; C07K 16/18; A61K 38/39
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/711 (2006.01); A61K 35/12 (2006.01); A61K 35/26 (2006.01); A61K 35/28 (2006.01); A61K 35/34 (2006.01); A61K 35/407 (2006.01); A61K 38/00 (2006.01); A61K 38/48 (2006.01); A61K 48/00 (2006.01); A61P 1/04 (2006.01); A61P 3/04 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 15/18 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/78 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/68 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); C12R 1/645 (2006.01)
CPC (source: EP KR)
A61P 1/04 (2018.01 - EP); A61P 3/04 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 15/18 (2018.01 - EP); A61P 17/02 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 27/02 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 14/00 (2013.01 - KR); C07K 14/78 (2013.01 - EP); A61K 38/00 (2013.01 - EP); C07K 2319/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9929856 A1 19990617; AT E319840 T1 20060315; AU 1718099 A 19990628; AU 1806599 A 19990628; AU 1808899 A 19990628; AU 742866 B2 20020117; AU 749904 B2 20020704; AU 753889 B2 20021031; CA 2312287 A1 19990617; CA 2313251 A1 19990617; CA 2313705 A1 19990617; CN 1284130 A 20010214; CN 1284134 A 20010214; CN 1322246 A 20011114; DE 69833794 D1 20060504; EP 1037983 A1 20000927; EP 1037985 A1 20000927; EP 1038011 A2 20000927; EP 1038011 B1 20060308; IL 136665 A0 20010614; IL 136667 A0 20010614; IL 136668 A0 20010614; JP 2001526031 A 20011218; JP 2001526040 A 20011218; JP 2002503449 A 20020205; KR 20010015867 A 20010226; KR 20010015868 A 20010226; KR 20010015869 A 20010226; WO 9929855 A1 19990617; WO 9929878 A2 19990617; WO 9929878 A3 19990916
DOCDB simple family (application)
US 9826058 W 19981208; AT 98962932 T 19981208; AU 1718099 A 19981208; AU 1806599 A 19981208; AU 1808899 A 19981208; CA 2312287 A 19981208; CA 2313251 A 19981208; CA 2313705 A 19981208; CN 98811932 A 19981208; CN 98811934 A 19981208; CN 98811953 A 19981208; DE 69833794 T 19981208; EP 98962006 A 19981208; EP 98962932 A 19981208; EP 98962966 A 19981208; IL 13666598 A 19981208; IL 13666798 A 19981208; IL 13666898 A 19981208; JP 2000524427 A 19981208; JP 2000524428 A 19981208; JP 2000524449 A 19981208; KR 20007006248 A 20000608; KR 20007006249 A 20000608; KR 20007006250 A 20000608; US 9825892 W 19981208; US 9826057 W 19981208