EP 1038016 A2 20000927 - NEEDLE-FREE INJECTION OF FORMULATED NUCLEIC ACID MOLECULES
Title (en)
NEEDLE-FREE INJECTION OF FORMULATED NUCLEIC ACID MOLECULES
Title (de)
NADELLOSES INJEKTION VON FORMULIERTE NUKLEINSÄURE MOLEKÜLE
Title (fr)
INJECTION SANS AIGUILLE DE MOLECULES D'ACIDE NUCLEIQUE FORMULES
Publication
Application
Priority
- US 9826823 W 19981216
- US 6975497 P 19971216
Abstract (en)
[origin: WO9931262A2] A novel method is provided for delivering nucleic acid molecules through and/or to the skin of mammals by needle-free injection. The method involves the incorporation of formulated nucleic acid molecules with devices for injecting the molecules by air, fluid and/or mechanical pressure. Disclosed are compositions and methods for enhancing the administration to and uptake of nucleic acids in a mammal. The methods disclosed provide an increased immune response by allowing the uptake of formulated nucleic acid molecules by a wide variety of cell types simultaneously. Also disclosed are examples which demonstrate that the combination of formulated nucleic acid molecules and needle-free injection methods results in immune responses which are superior to those obtained by conventional means of delivery. Methods for delivery, as well as methods for formulating nucleic acid molecules with various compounds, such as cationic complexing agents, polymeric and non-polymeric formulations, protective, interactive, non-condensing systems are also disclosed.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 9/12 (2006.01); A61K 9/127 (2006.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 47/02 (2006.01); A61K 47/32 (2006.01); A61K 47/42 (2006.01); A61K 47/44 (2006.01); A61K 48/00 (2006.01); A61M 5/30 (2006.01); A61P 1/16 (2006.01); A61P 5/10 (2006.01); A61P 31/20 (2006.01); A61P 35/00 (2006.01); C12M 1/00 (2006.01); C12N 15/87 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 5/10 (2017.12); A61P 31/20 (2017.12); A61P 35/00 (2017.12); C12N 15/87 (2013.01)
Citation (search report)
See references of WO 9931262A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9931262 A2 19990624; WO 9931262 A3 19990910; AU 1922999 A 19990705; CA 2315256 A1 19990624; EP 1038016 A2 20000927; JP 2003528024 A 20030924
DOCDB simple family (application)
US 9826823 W 19981216; AU 1922999 A 19981216; CA 2315256 A 19981216; EP 98964020 A 19981216; JP 2000539160 A 19981216