Global Patent Index - EP 1038016 A2

EP 1038016 A2 2000-09-27 - NEEDLE-FREE INJECTION OF FORMULATED NUCLEIC ACID MOLECULES

Title (en)

NEEDLE-FREE INJECTION OF FORMULATED NUCLEIC ACID MOLECULES

Title (de)

NADELLOSES INJEKTION VON FORMULIERTE NUKLEINSÄURE MOLEKÜLE

Title (fr)

INJECTION SANS AIGUILLE DE MOLECULES D'ACIDE NUCLEIQUE FORMULES

Publication

EP 1038016 A2 (EN)

Application

EP 98964020 A

Priority

  • US 9826823 W
  • US 6975497 P

Abstract (en)

[origin: WO9931262A2] A novel method is provided for delivering nucleic acid molecules through and/or to the skin of mammals by needle-free injection. The method involves the incorporation of formulated nucleic acid molecules with devices for injecting the molecules by air, fluid and/or mechanical pressure. Disclosed are compositions and methods for enhancing the administration to and uptake of nucleic acids in a mammal. The methods disclosed provide an increased immune response by allowing the uptake of formulated nucleic acid molecules by a wide variety of cell types simultaneously. Also disclosed are examples which demonstrate that the combination of formulated nucleic acid molecules and needle-free injection methods results in immune responses which are superior to those obtained by conventional means of delivery. Methods for delivery, as well as methods for formulating nucleic acid molecules with various compounds, such as cationic complexing agents, polymeric and non-polymeric formulations, protective, interactive, non-condensing systems are also disclosed.

IPC 1-7 (main, further and additional classification)

C12N 15/87; A61K 48/00

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 9/12 (2006.01); A61K 9/127 (2006.01); A61K 31/7105 (2006.01); A61K 31/711 (2006.01); A61K 47/02 (2006.01); A61K 47/32 (2006.01); A61K 47/42 (2006.01); A61K 47/44 (2006.01); A61K 48/00 (2006.01); A61M 5/30 (2006.01); A61P 1/16 (2006.01); A61P 5/10 (2006.01); A61P 31/20 (2006.01); A61P 35/00 (2006.01); C12M 1/00 (2006.01); C12N 15/87 (2006.01)

CPC (invention and additional information)

C12N 15/87 (2013.01)

Citation (search report)

See references of WO 9931262A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9931262 A2 19990624; WO 9931262 A3 19990910; AU 1922999 A 19990705; CA 2315256 A1 19990624; EP 1038016 A2 20000927; JP 2003528024 A 20030924

INPADOC legal status


2004-01-07 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030701

2000-09-27 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000714

2000-09-27 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE