Global Patent Index - EP 1038178 A1

EP 1038178 A1 2000-09-27 - DIAGNOSTIC ASSAY FOR MATRIX METALLOPROTEINASE 9 AND USE THEREOF

Title (en)

DIAGNOSTIC ASSAY FOR MATRIX METALLOPROTEINASE 9 AND USE THEREOF

Title (de)

DIAGNOSTISCHES VERFAHREN FÜR MATRIX-METALLOPROTEINASE 9

Title (fr)

METHODE DIAGNOSTIQUE DE DETECTION DE METALLOPROTEASE MATRICIELLE-9 ET UTILISATION DE LADITE METHODE

Publication

EP 1038178 A1 (EN)

Application

EP 99953097 A

Priority

  • US 9923443 W
  • US 16852698 A

Abstract (en)

[origin: WO0020860A1] The present invention employs an improved immunoassay that detects all forms of MMP-9 (both the form complexed with TIMP and the "free" uncomplexed form) in biological samples including human serum and plasma. Using this immunoassay the present inventors have surprisingly discovered that a much higher degree of detection and quantification is possible than with prior assays. The assay is preferably a capture assay using two antibodies to MMP-9 that do not compete with each other (i.e., bind to distinct epitopes). The epitopes that are bound to must be exposed in both the complexed MMP-9 as well as the free MMP-9.

IPC 1-7 (main, further and additional classification)

G01N 33/53; G01N 33/567; G01N 33/574

IPC 8 full level (invention and additional information)

C12N 9/64 (2006.01); G01N 33/543 (2006.01); G01N 33/573 (2006.01); G01N 33/574 (2006.01)

CPC (invention and additional information)

G01N 33/573 (2013.01)

Citation (search report)

See references of WO 0020860A1

Designated contracting state (EPC)

CH DE GB LI

EPO simple patent family

WO 0020860 A1 20000413; AU 6511199 A 20000426; EP 1038178 A1 20000927; JP 2002526772 A 20020820

INPADOC legal status


2004-05-19 [RBV] DESIGNATED CONTRACTING STATES (CORRECTION):

- Designated State(s): CH DE GB LI

2003-02-26 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020502

2000-09-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000628

2000-09-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE