EP 1039886 A1 20001004 - HIV/FIV PROTEASE INHIBITORS HAVING A SMALL P3 RESIDUE
Title (en)
HIV/FIV PROTEASE INHIBITORS HAVING A SMALL P3 RESIDUE
Title (de)
EIN KLEINER P3 REST AUFWEISENDE HIV/FIV PROTEASE HEMMER
Title (fr)
INHIBITEURS DE PROTEASES DE VIH/VIF PRESENTANT UN PETIT RESTE P3
Publication
Application
Priority
- US 9825964 W 19981208
- US 6795997 P 19971208
Abstract (en)
[origin: WO9929311A1] With the help of X-ray structural analyses of drug-resistant HIV proteases and molecular modeling, a new type of inhibitor with a small P3 residue has been developed. These inhibitors are effective against HIV and its drug-resistant mutants, as well as FIV. Modification of existing HIV protease inhibitors by reducing the size of the P3 residue has the same effect. This finding provides a new strategy for the development of HIV protease inhibitors effective against the wild type and drug-resistant mutants and further supports that FIV protease is a useful model for drug-resistant HIV proteases, which often are developed through reduction in size of the binding region for the P3 group or the combined P3 and P1 groups.
IPC 1-7
A61K 31/045; A61K 31/13; A61K 31/135; A61K 31/165; A61K 31/38; A61K 31/405; A61K 31/47; A61K 38/05; C07C 205/02; C07C 211/09; C07C 215/18; C07D 207/16; C07D 217/16; C07D 217/26; C07D 277/24; C07D 277/28; C07K 5/062; C07K 5/065
IPC 8 full level
C07D 207/16 (2006.01); C07D 213/40 (2006.01); C07D 217/26 (2006.01); C07D 277/24 (2006.01); C07D 277/28 (2006.01); C07D 401/12 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); C07K 5/065 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07D 207/16 (2013.01); C07D 213/40 (2013.01); C07D 217/26 (2013.01); C07D 277/28 (2013.01); C07D 401/12 (2013.01); C07K 5/06026 (2013.01); C07K 5/06043 (2013.01); C07K 5/06052 (2013.01); C07K 5/0606 (2013.01); C07K 5/06069 (2013.01); C07K 5/06078 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9929311 A1 19990617; AU 1904599 A 19990628; EP 1039886 A1 20001004; EP 1039886 A4 20010516
DOCDB simple family (application)
US 9825964 W 19981208; AU 1904599 A 19981208; EP 98963800 A 19981208