EP 1039910 A1 20001004 - USE OF QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS FOR TREATING COLONIC POLYPS
Title (en)
USE OF QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS FOR TREATING COLONIC POLYPS
Title (de)
VERWENDUNG VON CHINAZOLINE DERIVATEN ALS TYROSINE KINASE HEMMER ZUR BEHANDLUNG VON DICKDARMPOLYPEN
Title (fr)
TRAITEMENT DES POLYPES DU COLON PAR DES INHIBITEURS DE LA TYROSINE KINASE A BASE DE DERIVES DE QUINAZOLINE
Publication
Application
Priority
- US 9823549 W 19981104
- US 96508497 A 19971106
Abstract (en)
[origin: WO9924037A1] This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having formula (I), wherein X is phenyl which is optionally substituted; R and R1 are each independently, hydrogen, halogen, alkyl, alkoxy, hydroxy or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy or trifluoromethyl; Y is a radical selected from the group consisting of formulae (II), (III), (IV), (V), (VI), (VII) and (VIII). R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n = 2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.
IPC 1-7
IPC 8 full level
A61K 31/505 (2006.01); C07D 239/94 (2006.01); A61K 31/517 (2006.01); A61P 1/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP KR)
A61K 31/505 (2013.01 - EP KR); A61P 1/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9924037 A1 19990520; AR 016415 A1 20010704; AU 1308799 A 19990531; BR 9814116 A 20001003; CA 2306155 A1 19990520; CN 1278176 A 20001227; EP 1039910 A1 20001004; HU P0004286 A2 20011128; HU P0004286 A3 20020128; IL 135622 A0 20010520; JP 2001522802 A 20011120; KR 20010031813 A 20010416; NO 20002166 D0 20000427; NO 20002166 L 20000628; NZ 503991 A 20011130; PL 340800 A1 20010226; ZA 9810134 B 20000505
DOCDB simple family (application)
US 9823549 W 19981104; AR P980105592 A 19981105; AU 1308799 A 19981104; BR 9814116 A 19981104; CA 2306155 A 19981104; CN 98810806 A 19981104; EP 98956600 A 19981104; HU P0004286 A 19981104; IL 13562298 A 19981104; JP 2000520129 A 19981104; KR 20007004883 A 20000504; NO 20002166 A 20000427; NZ 50399198 A 19981104; PL 34080098 A 19981104; ZA 9810134 A 19981105