Global Patent Index - EP 1039914 A4

EP 1039914 A4 20070627 - CYCLOOXYGENASE-2 INHIBITION

Title (en)

CYCLOOXYGENASE-2 INHIBITION

Title (de)

CYCLOOXYGENASE-2 HEMMUNG

Title (fr)

. INHIBITION DE LA CYCLOOXYGENASE-2

Publication

EP 1039914 A4 20070627 (EN)

Application

EP 98961802 A 19981207

Priority

  • US 9825206 W 19981207
  • US 6995597 P 19971217

Abstract (en)

[origin: WO9930721A1] Selective inhibitors of cyclooxygenase-2 are used to treat liver disease and in combination with anti-viral drugs to treat virus-caused liver disorders. Selective inhibitors of cyclooxygenase-2 which also inhibit the synthesis of cyclooxygenase-2 improve over the efficacy of conventional selective inhibitors of cyclooxygenase-2 in the treatment of inflammatory conditions, Alzheimer's disease and cancer.

IPC 1-7

A61K 31/365; A61K 31/415; A61K 31/42; C07D 231/12; C07D 263/32

IPC 8 full level

A61K 31/655 (2006.01); C07D 231/12 (2006.01); C07D 263/32 (2006.01)

CPC (source: EP)

A61K 31/365 (2013.01); A61K 31/415 (2013.01); A61K 31/421 (2013.01); A61K 31/655 (2013.01); C07D 231/12 (2013.01); C07D 263/32 (2013.01)

Citation (search report)

  • [XY] US 5474995 A 19951212 - DUCHARME YVES [CA], et al
  • [X] US 5436265 A 19950725 - BLACK CAMERON [CA], et al
  • [X] WO 9729776 A1 19970821 - SEARLE & CO [US], et al
  • [X] WO 9729775 A1 19970821 - SEARLE & CO [US], et al
  • [XY] NANJI AMIN A ET AL: "Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat", GASTROENTEROLOGY, vol. 112, no. 3, 1997, pages 943 - 951, XP002422458, ISSN: 0016-5085
  • [Y] ANDREONE P ET AL: "Interferon-[alpha] plus indomethacin combined therapy in HBeAg positive chronic hepatitis B non-responder to a previous IFN[alpha] course: Results of a pilot study", INTERNATIONAL HEPATOLOGY COMMUNICATIONS, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 5, no. 3, 1996, pages 151 - 159, XP002313973, ISSN: 0928-4346
  • [A] ANDREONE P ET AL: "Indomethacin increases 2',5'-oligoadenylate synthetase release by cultured liver tissue of patients with HCV chronic active hepatitis", INTERNATIONAL HEPATOLOGY COMMUNICATIONS 1994 NETHERLANDS, vol. 2, no. 5, 1994, pages 289 - 294, XP002422459, ISSN: 0928-4346
  • [A] ANDREONE P ET AL: "INDOMETHACIN ENHANCES SERUM 2'5'-OLIGOADENYLATE SYNTHETASE IN PATIENTS WITH HEPATITIS B AND C VIRUS CHRONIC ACTIVE HEPATITIS", JOURNAL OF HEPATOLOGY, MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN, DK, vol. 21, no. 6, 1994, pages 984 - 988, XP009042789, ISSN: 0168-8278
  • [A] HEINRICH D ET AL: "Treatment of chronic viral hepatitis with acetylsalicylic acid", SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT, vol. 125, no. 15, 1995, pages 755 - 757, XP008075508, ISSN: 0036-7672
  • See references of WO 9930721A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9930721 A1 19990624; AU 1703799 A 19990705; CA 2313049 A1 19990624; EP 1039914 A1 20001004; EP 1039914 A4 20070627

DOCDB simple family (application)

US 9825206 W 19981207; AU 1703799 A 19981207; CA 2313049 A 19981207; EP 98961802 A 19981207