EP 1039929 A1 20001004 - ACTIVATED T-CELLS AND THEIR USES
Title (en)
ACTIVATED T-CELLS AND THEIR USES
Title (de)
AKTIVIERTEN T-ZELLEN UND DEREN VERWENDUNG
Title (fr)
LYMPHOCYTES ACTIVES ET LEURS UTILISATIONS
Publication
Application
Priority
US 9814715 W 19980721
Abstract (en)
[origin: WO9934827A1] The present invention relates to compositions and methods for the treatment or diagnosis of injury of the central nervous system (CNS). In particular, the invention relates to compositions comprising activated T-cells which are used to deliver (a) a diagnostic substance or (b) a therapeutic substance to a site of damage of the CNS caused by injury or disease. The invention also relates to pharmaceutical compositions comprising antiself T-cells that recognize antigens present in a greater concentration in the CNS compared to the circulation and methods of use thereof to prevent or inhibit degeneration of nerves within the CNS. The invention also relates to pharmaceutical compositions comprising an antigen (or derivative thereof) present in a greater concentration in the CNS compared to the circulation (NS-specific antigen or derivative) and methods of use thereof to prevent or inhibit degeneration of nerves within the CNS. The substance-delivering activated T-cell composition of the present invention may be administered alone or in combination with NS-specific T-cells or NS-specific antigen or in combination with NS-specific T-cells and NS-specific antigen.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/28 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01); A61K 49/00 (2006.01); A61K 51/00 (2006.01); A61P 9/10 (2006.01); A61P 17/02 (2006.01); A61P 21/02 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 27/06 (2006.01); C12N 5/10 (2006.01); A61K 35/12 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61K 38/1709 (2013.01); A61K 39/0007 (2013.01); A61K 39/4611 (2023.05); A61K 39/4621 (2023.05); A61K 39/46433 (2023.05); A61P 9/10 (2018.01); A61P 17/02 (2018.01); A61P 21/02 (2018.01); A61P 25/14 (2018.01); A61P 25/16 (2018.01); A61P 25/28 (2018.01); A61P 27/06 (2018.01); A61K 35/12 (2013.01); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9934827 A1 19990715; EP 1039929 A1 20001004; JP 2002500199 A 20020108
DOCDB simple family (application)
US 9814715 W 19980721; EP 98936862 A 19980721; JP 2000527274 A 19980721