EP 1040110 A1 20001004 - 5-¬4-¬2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY BENZYL THIAZOLIDINE-2,4-DIONE,MALEIC ACID SALT,HYDRATE AS PHARMACEUTICAL
Title (en)
5-¬4-¬2-(N-METHYL-N-(2-PYRIDYL)AMINO)ETHOXY BENZYL THIAZOLIDINE-2,4-DIONE,MALEIC ACID SALT,HYDRATE AS PHARMACEUTICAL
Title (de)
5-¬4-¬(N-METHYL-N-(2PYRIDYL)AMINO)ÄTHOXY BENZYL THIAZOLIDIN-2,4-DION,MALEINSÄURESALZ,HYDRATE ALS ARZNEIMITTEL
Title (fr)
PRODUIT PHARMACEUTIQUE CONSTITUE PAR UN HYDRATE, SEL DE L'ACIDE MALEIQUE, DE FORMULE 5- 4- 2- (N-METHYL-N- (2-PYRIDYL)AMINO) ETHOXY BENZYL THIAZOLIDINE-2, 4-DIONE
Publication
Application
Priority
- EP 9808155 W 19981214
- GB 9726566 A 19971216
Abstract (en)
[origin: WO9931095A1] A hydrate of 5-[4-[2- (N-methyl-N- (2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2, 4-dione, maleic acid salt, characterised in that it: (i) comprises water in the range of from 0.4 to 2.5 %w/w; and (ii) provides an infra red spectrum containing peaks at 1749, 1703, 1645, 1623, 1365 and 736 cm<-1>; and/or (iii) provides an X-ray powder diffraction (XRPD) pattern substantially as set out in Figure II and/or (iv) provides a Raman spectrum containing peaks at 3106, 3069, 3002, 2961, 1750, 1718, 1684, 1385, 1335, 1229, 1078, 917, 428 and 349 cm<-1> and/or (iv) provides a solid-state nuclear magnetic resonance spectrum containing chemical shifts substantially as set out in Table I; a process for the preparation of such a compound, a pharmaceutical composition containing such a compound and the use of such a compound or composition in medicine.
IPC 1-7
IPC 8 full level
A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61P 3/10 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP KR)
A61K 31/425 (2013.01 - KR); A61P 3/00 (2018.01 - EP); A61P 3/10 (2018.01 - EP); C07D 417/12 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 9931095 A1 19990624; AP 1365 A 20050126; AP 2000001831 A0 20000630; AR 017214 A1 20010822; AU 1967999 A 19990705; BG 104603 A 20010330; BG 64988 B1 20061130; BR 9813600 A 20001010; CA 2314107 A1 19990624; CN 101302215 A 20081112; CN 101381367 A 20090311; CN 1281453 A 20010124; CO 4980880 A1 20001127; CZ 20002204 A3 20001115; CZ 299965 B6 20090107; DZ 2681 A1 20040620; EA 004260 B1 20040226; EA 200000654 A1 20001225; EG 22337 A 20021231; EP 1040110 A1 20001004; EP 1661895 A1 20060531; GB 9726566 D0 19980211; HR P20000408 A2 20000831; HR P20000408 B1 20080430; HU P0100509 A2 20020529; HU P0100509 A3 20020628; IL 136424 A0 20010614; IL 136424 A 20031210; IN 192487 B 20040424; JP 2002508373 A 20020319; KR 100549142 B1 20060203; KR 20010033141 A 20010425; MA 26580 A1 20041220; MY 135612 A 20080530; NO 20003069 D0 20000615; NO 20003069 L 20000615; NO 317254 B1 20040927; OA 11766 A 20050719; PE 20000058 A1 20000226; PL 341146 A1 20010326; RS 50126 B 20090325; SA 99191115 B1 20061011; SK 286618 B6 20090205; SK 9172000 A3 20010118; TR 199802625 A2 19991021; TR 199802625 A3 19991021; TR 200001799 T2 20010122; TW 509690 B 20021111; UA 72198 C2 20050215; UY 25304 A1 20001229; UY 25308 A1 19990719; YU 36300 A 20040312; ZA 9811506 B 20001106
DOCDB simple family (application)
EP 9808155 W 19981214; AP 2000001831 A 19981214; AR P980106370 A 19981215; AU 1967999 A 19981214; BG 10460300 A 20000713; BR 9813600 A 19981214; CA 2314107 A 19981214; CN 200810087030 A 19981214; CN 200810087031 A 19981214; CN 98812089 A 19981214; CO 98074834 A 19981216; CZ 20002204 A 19981214; DZ 980291 A 19981215; EA 200000654 A 19981214; EG 155698 A 19981215; EP 05077331 A 19981214; EP 98964510 A 19981214; GB 9726566 A 19971216; HR P20000408 A 20000616; HU P0100509 A 19981214; IL 13642498 A 19981214; IN 3772DE1998 A 19981216; JP 2000539019 A 19981214; KR 20007006515 A 20000615; MA 25389 A 19981214; MY PI9805674 A 19981215; NO 20003069 A 20000615; OA 1200000178 A 19981214; PE 00123398 A 19981216; PL 34114698 A 19981214; SA 99191115 A 19990227; SK 9172000 A 19981214; TR 200001799 T 19981214; TR 9802625 A 19981216; TW 87121121 A 19981216; UA 2000063485 A 19981214; UY 25304 A 19981215; UY 25308 A 19981215; YU 36300 A 19981214; ZA 9811506 A 19981215