Global patent index - EP 1040196 A2

EP 1040196 A2 2000-10-04 - TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE

Title (en)

TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE

Title (de)

TRANSGENES TIERMODEL FÜR DEGENERATIVE ERKRANKUNGEN DES KNORPELS

Title (fr)

MODELE ANIMAL TRANSGENIQUE DE LUTTE CONTRE DES MALADIES DEGENERATIVES DU CARTILAGE

Publication

EP 1040196 A2 (EN)

Application

EP 98964125 A

Priority

  • US 9827056 W
  • US 6831297 P
  • US 99468997 A

Abstract (en)

[origin: WO9931969A2] The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.

IPC 1-7 (main, further and additional classification)

C12N 15/57; A01K 67/027; A61K 49/00; C12N 5/10; C12N 9/64

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A61K 45/00 (2006.01); A61P 19/02 (2006.01); A61P 19/04 (2006.01); A61P 29/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/64 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01)

CPC (invention and additional information)

C12N 15/8509 (2013.01); A01K 67/0275 (2013.01); C12N 9/6491 (2013.01); A01K 2217/05 (2013.01); A01K 2217/072 (2013.01); A01K 2217/20 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0393 (2013.01); C12N 2830/008 (2013.01)

Citation (search report)

See references of WO 9931969A3

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9931969 A2 19990701; WO 9931969 A3 19991125; AU 1931699 A 19990712; AU 2003257928 A1 20031120; AU 2003257928 B2 20070712; CA 2314357 A1 19990701; CZ 20002201 A3 20011114; EP 1040196 A2 20001004; IL 136626 D0 20010614; JP 2002533055 A 20021008; KR 100685105 B1 20070222; KR 20050109080 A 20051117

INPADOC legal status

2009-09-30 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20090413

2005-05-25 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20050408

2002-06-19 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WYETH

- Ref Legal Event Code: RAP1

2000-10-04 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000718

2000-10-04 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE