EP 1040196 A2 20001004 - TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE
Title (en)
TRANSGENIC ANIMAL MODEL FOR DEGENERATIVE DISEASES OF CARTILAGE
Title (de)
TRANSGENES TIERMODEL FÜR DEGENERATIVE ERKRANKUNGEN DES KNORPELS
Title (fr)
MODELE ANIMAL TRANSGENIQUE DE LUTTE CONTRE DES MALADIES DEGENERATIVES DU CARTILAGE
Publication
Application
Priority
- US 9827056 W 19981218
- US 6831297 P 19971219
- US 99468997 A 19971219
Abstract (en)
[origin: WO9931969A2] The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 45/00 (2006.01); A61P 19/02 (2006.01); A61P 19/04 (2006.01); A61P 29/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/64 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP KR)
A01K 67/027 (2013.01 - KR); A01K 67/0275 (2013.01 - EP); A61P 19/02 (2017.12 - EP); A61P 19/04 (2017.12 - EP); A61P 29/00 (2017.12 - EP); C12N 9/6491 (2013.01 - EP); C12N 15/8509 (2013.01 - EP); A01K 2217/05 (2013.01 - EP); A01K 2217/072 (2013.01 - EP); A01K 2217/20 (2013.01 - EP); A01K 2227/105 (2013.01 - EP); A01K 2267/03 (2013.01 - EP); A01K 2267/0393 (2013.01 - EP); C12N 2830/008 (2013.01 - EP)
Citation (search report)
See references of WO 9931969A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9931969 A2 19990701; WO 9931969 A3 19991125; AU 1931699 A 19990712; AU 2003257928 A1 20031120; AU 2003257928 B2 20070712; CA 2314357 A1 19990701; CZ 20002201 A3 20011114; EP 1040196 A2 20001004; IL 136626 A0 20010614; JP 2002533055 A 20021008; KR 100558288 B1 20060310; KR 100685105 B1 20070222; KR 20010033289 A 20010425; KR 20050109080 A 20051117
DOCDB simple family (application)
US 9827056 W 19981218; AU 1931699 A 19981218; AU 2003257928 A 20031029; CA 2314357 A 19981218; CZ 20002201 A 19981218; EP 98964125 A 19981218; IL 13662698 A 19981218; JP 2000524983 A 19981218; KR 20007006731 A 20000617; KR 20057020039 A 20051021