Global patent index - EP 1041986 A1

EP 1041986 A1 2000-10-11 - PHARMACEUTICALLY ACTIVE COMPOUND AND METHODS OF USE

Title (en)

PHARMACEUTICALLY ACTIVE COMPOUND AND METHODS OF USE

Title (de)

PHARMAZEUTISCH AKTIVE VERBINDUNG UND VERFAHREN ZUR VERWENDUNG

Title (fr)

COMPOSE ACTIF DU POINT DE VUE PHARMACEUTIQUE ET SES METHODES D'UTILISATION

Publication

EP 1041986 A1 (EN)

Application

EP 98953372 A

Priority

  • US 9821395 W
  • US 6346997 P

Abstract (en)

[origin: WO9918962A1] The present invention relates to racemic and optically active N-(2-chloro-5- methylthiophenyl) -N'-(3- methylsulfinylphenyl) -N'-methylguanidine, N-(2-chloro-5- methylsulfinylphenyl) -1-(7-trifluoromethyl -1,2,3,4- tetrahydroquinolinyl) carboximidamide, and N-(3-methylsulfinylphenyl) -N-methyl-N'- (2-chloro-5- methoxyphenyl) guanidine and pharmaceutically acceptable salts thereof, and pharmaceutical compositions and therapeutic methods of treatment that comprise such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.

IPC 1-7 (main, further and additional classification)

A61K 31/47; A61K 31/155; C07C 215/14; C07D 215/14

IPC 8 full level (invention and additional information)

C07D 215/12 (2006.01); A61K 31/155 (2006.01); A61K 31/47 (2006.01); A61P 1/08 (2006.01); A61P 9/00 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 31/04 (2006.01); A61P 43/00 (2006.01); C07C 323/44 (2006.01); C07D 215/48 (2006.01)

CPC (invention and additional information)

C07D 215/48 (2013.01); C07C 323/44 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9918962 A1 19990422; AU 1076799 A 19990503; CA 2306276 A1 19990422; EP 1041986 A1 20001011; EP 1041986 A4 20010321; JP 2001519393 A 20011023

INPADOC legal status

2005-05-18 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20041116

2003-04-02 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030219

2001-03-21 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20010202

2001-03-21 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2001-03-21 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- Free Format Text: 7A 61K 31/47 A, 7A 61K 31/155 B, 7C 07C 215/14 B, 7C 07D 215/14 B, 7C 07C 323/44 B, 7C 07D 215/48 B

2000-10-11 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000510

2000-10-11 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-10-11 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000510;LT PAYMENT 20000510;LV PAYMENT 20000510;MK PAYMENT 20000510;RO PAYMENT 20000510;SI PAYMENT 20000510