EP 1041999 A1 20001011 - THROMBOGENIC POLYPEPTIDE CHIMERAS AND CONJUGATES HAVING ACTIVITY DEPENDENT UPON ASSOCIATION WITH TUMOR VASCULAR ENDOTHELIUM

Title (en)

THROMBOGENIC POLYPEPTIDE CHIMERAS AND CONJUGATES HAVING ACTIVITY DEPENDENT UPON ASSOCIATION WITH TUMOR VASCULAR ENDOTHELIUM

Title (de)

THROMBOGENE POLYPEPTID-CHIMÄREN UND KONJUGATE, DIE EINE VON DER ASSOZIATION MIT VASKULÄREM ENDOTHELIUM ABHÄNGIGE AKTIVITÄT BESITZEN

Title (fr)

CHIMERES ET CONJUGUES POLYPEPTIDIQUES THROMBOGENES PRESENTANT UNE ACTIVITE DEPENDANT DE L'ASSOCIATION AVEC L'ENDOTHELIUM VASCULAIRE TUMORAL

Publication

EP 1041999 A1 20001011 (EN)

Application

EP 98965484 A 19981222

Priority

US 9827498 W 19981222
US 99674497 A 19971223

Abstract (en)

[origin: WO9932143A1] Thrombosis-initiating chimeric polypeptides and conjugates, where Figure 1 portrays one of the disclosed examples of the latter, are provided, as well as compositions comprising same and nucleic acid constructs encoding same. At least one component of a chimera or a conjugate is specific for one or more external features of the vascular endothelium of vessels nourishing a tumor and at least one thrombotic component is substantially inactive when not associated with said tumor vascular endothelium, permitting specific destruction of cancer cells of solid tumors in an animal.

IPC 1-7

A61K 38/36; A61K 38/37; A61K 38/57; A61K 39/395; C07K 1/10; C07K 14/475; C07K 14/755; C07K 14/81; C07K 16/28; C07K 16/30; C07K 16/46; C07K 19/00; C12N 9/50; C12N 15/57; C12N 15/62; C12N 15/70

IPC 8 full level

A61K 47/48 (2006.01); A61K 49/00 (2006.01); C07K 14/705 (2006.01); C07K 14/745 (2006.01); C12N 9/68 (2006.01); C12N 15/57 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61K 47/6425 (2017.07); A61K 49/0004 (2013.01); C07K 14/70596 (2013.01); C07K 14/745 (2013.01); C12N 9/6435 (2013.01); C12Y 304/21007 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)

Citation (search report)

See references of WO 9932143A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9932143 A1 19990701; AU 2094199 A 19990712; CA 2318434 A1 19990701; EP 1041999 A1 20001011

DOCDB simple family (application)

US 9827498 W 19981222; AU 2094199 A 19981222; CA 2318434 A 19981222; EP 98965484 A 19981222