EP 1042003 A1 20001011 - DELIVERY OF LONG LASTING THERAPEUTIC AGENTS BY FORMING COVALENT ATTACHMENTS IN VIVO
Title (en)
DELIVERY OF LONG LASTING THERAPEUTIC AGENTS BY FORMING COVALENT ATTACHMENTS IN VIVO
Title (de)
VERABREICHUNG ÜBER LÄNGERE ZEIT WIRKSAMER THERAPEUTISCHEN MITTEL DURCH BILDUNG KOVALENTER BINDUNGEN IN VIVO
Title (fr)
APPORT LOCAL D'AGENTS THERAPEUTIQUES A ACTION PROLONGEE
Publication
Application
Priority
- US 9906344 W 19990323
- US 7897498 P 19980323
- US 8635298 P 19980520
- US 8620598 P 19980521
- US 10739198 P 19981106
Abstract (en)
[origin: WO9948536A2] Methods of and compositions for localized delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest are disclosed. Therapeutic agents useful in the invention include wound healing agents, antibiotics, anti-inflammatories, anti-oxidants, anti-proliferatives, immunosupressants, anti-infective and anti-cancer agents.
[origin: WO9948536A2] This invention relates to the field of therapeutic agents in medicine. In particular, this invention relates to the field of localized delivery of therapeutic agents wherein the agents are capable of covalently bonding to a site of interest <i>in vivo</i>, to provide increased tissue retention and pharmacodynamic duration of therapeutic benefit for the given drug. In addition, the invention includes the non-specific labeling of fixed blood proteins and tissues with N-Hydroxy-Succinimide (NHS)-drugs and sulfo-NHS drugs, although other reactive groups, which are functional in an aqueous medium such as blood, may also be employed.
IPC 1-7
IPC 8 full level
A61K 9/00 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 47/42 (2006.01); A61K 47/48 (2006.01); A61K 51/00 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 17/02 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 47/54 (2017.07); A61P 9/00 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 17/02 (2017.12); A61P 31/18 (2017.12); A61P 35/00 (2017.12)
Citation (search report)
See references of WO 9948536A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9948536 A2 19990930; WO 9948536 A3 20010517; AU 3452799 A 19991018; AU 748496 B2 20020606; CA 2291066 A1 19990930; EP 1042003 A1 20001011; IL 133053 A0 20010319; JP 2002512640 A 20020423
DOCDB simple family (application)
US 9906344 W 19990323; AU 3452799 A 19990323; CA 2291066 A 19990323; EP 99916153 A 19990323; IL 13305399 A 19990323; JP 54845699 A 19990323