EP 1042329 A1 20001011 - NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION, PHARMACEUTICAL, COMPOSITIONS CONTAINING THEM AND USE FOR PREPARING MEDICINES
Title (en)
NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION, PHARMACEUTICAL, COMPOSITIONS CONTAINING THEM AND USE FOR PREPARING MEDICINES
Title (de)
FARNESYLTRANSFERASE INHIBITOREN, VERFAHREN ZU IHRER HERSTELLUNG, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS ARZNEIMITTEL
Title (fr)
NOUVEAUX INHIBITEURS DE FARNESYLE TRANSFERASE, LEUR PREPARATION, LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT ET LEUR UTILISATION POUR LA PREPARATION DE MEDICAMENTS
Publication
Application
Priority
- FR 9802804 W 19981221
- FR 9716335 A 19971223
- US 7380098 P 19980205
Abstract (en)
[origin: WO9933834A1] The invention concerns novel products of general formula (I), their preparation, the pharmaceutical compositions containing them and their use for preparing medicines. (I) In the general formula (I): Het represents a monocyclic or polycyclic system, for which at least one of the cycles contain 1 to 4 heteroatoms; Ar represents an optionally substituted phenyl radical, a phenyl radical substituted for a heterocycle, a polycyclic or heterocyclic aromatic radical; R represents a -COOH, -COOR4, -CON(R5)(R6) radical in which R4 = alkyl, R5 = H, alkyl, R6 = alkyl, hydrogen, hydroxy, amino optionally substituted, alkoxy; R1, R2 = hydrogen, halogen, alkyl, alkoxy, alkylthio, alkoxycarbonyl; R3 = hydrogen, alkyl, alkylthio; X = methylene, alken-1,1-diyl, cycloalkan-1,1-diyl; in racemic form or the optical isomers or mixtures of their optical isomers, and the salts of the product of general formula (I). The products of general formula (I) are farnesyl transferase inhibitors.
IPC 1-7
C07D 495/08; A61K 31/40; C07D 409/04; C07D 403/04; C07D 491/08; C07D 487/08; C07D 471/08
IPC 8 full level
A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61P 1/00 (2006.01); A61P 1/16 (2006.01); A61P 1/18 (2006.01); A61P 11/00 (2006.01); A61P 13/08 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 19/00 (2006.01); A61P 21/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 43/00 (2006.01); C07D 209/44 (2006.01); C07D 409/04 (2006.01); C07D 487/04 (2006.01); C07D 487/08 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 495/08 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 1/16 (2017.12); A61P 1/18 (2017.12); A61P 11/00 (2017.12); A61P 13/08 (2017.12); A61P 13/12 (2017.12); A61P 15/00 (2017.12); A61P 17/00 (2017.12); A61P 17/06 (2017.12); A61P 19/00 (2017.12); A61P 21/00 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 43/00 (2017.12); C07D 209/44 (2013.01); C07D 409/04 (2013.01); C07D 487/08 (2013.01); C07D 495/08 (2013.01)
Citation (search report)
See references of WO 9933834A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9933834 A1 19990708; AU 1767599 A 19990719; CA 2315144 A1 19990708; EP 1042329 A1 20001011; JP 2001527078 A 20011225
DOCDB simple family (application)
FR 9802804 W 19981221; AU 1767599 A 19981221; CA 2315144 A 19981221; EP 98962528 A 19981221; JP 2000526514 A 19981221