Global patent index - EP 1042329 A1

EP 1042329 A1 2000-10-11 - NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION, PHARMACEUTICAL, COMPOSITIONS CONTAINING THEM AND USE FOR PREPARING MEDICINES

Title (en)

NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION, PHARMACEUTICAL, COMPOSITIONS CONTAINING THEM AND USE FOR PREPARING MEDICINES

Title (de)

FARNESYLTRANSFERASE INHIBITOREN, VERFAHREN ZU IHRER HERSTELLUNG, DIESE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN UND IHRE VERWENDUNG ALS ARZNEIMITTEL

Title (fr)

NOUVEAUX INHIBITEURS DE FARNESYLE TRANSFERASE, LEUR PREPARATION, LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT ET LEUR UTILISATION POUR LA PREPARATION DE MEDICAMENTS

Publication

EP 1042329 A1 (FR)

Application

EP 98962528 A

Priority

  • FR 9802804 W
  • FR 9716335 A
  • US 7380098 P

Abstract (en)

[origin: WO9933834A1] The invention concerns novel products of general formula (I), their preparation, the pharmaceutical compositions containing them and their use for preparing medicines. (I) In the general formula (I): Het represents a monocyclic or polycyclic system, for which at least one of the cycles contain 1 to 4 heteroatoms; Ar represents an optionally substituted phenyl radical, a phenyl radical substituted for a heterocycle, a polycyclic or heterocyclic aromatic radical; R represents a -COOH, -COOR4, -CON(R5)(R6) radical in which R4 = alkyl, R5 = H, alkyl, R6 = alkyl, hydrogen, hydroxy, amino optionally substituted, alkoxy; R1, R2 = hydrogen, halogen, alkyl, alkoxy, alkylthio, alkoxycarbonyl; R3 = hydrogen, alkyl, alkylthio; X = methylene, alken-1,1-diyl, cycloalkan-1,1-diyl; in racemic form or the optical isomers or mixtures of their optical isomers, and the salts of the product of general formula (I). The products of general formula (I) are farnesyl transferase inhibitors.

IPC 1-7 (main, further and additional classification)

C07D 495/08; A61K 31/40; C07D 403/04; C07D 409/04; C07D 471/08; C07D 487/08; C07D 491/08

IPC 8 full level (invention and additional information)

C07D 487/04 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61P 1/00 (2006.01); A61P 1/16 (2006.01); A61P 1/18 (2006.01); A61P 11/00 (2006.01); A61P 13/08 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 19/00 (2006.01); A61P 21/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 43/00 (2006.01); C07D 209/44 (2006.01); C07D 409/04 (2006.01); C07D 487/08 (2006.01); C07D 491/048 (2006.01); C07D 495/04 (2006.01); C07D 495/08 (2006.01)

CPC (invention and additional information)

C07D 409/04 (2013.01); C07D 209/44 (2013.01); C07D 487/08 (2013.01); C07D 495/08 (2013.01)

Citation (search report)

See references of WO 9933834A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9933834 A1 19990708; AU 1767599 A 19990719; CA 2315144 A1 19990708; EP 1042329 A1 20001011; JP 2001527078 A 20011225

INPADOC legal status

2003-06-11 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20021123

2001-12-19 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20011106

2000-10-11 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000621

2000-10-11 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE