EP 1043987 A1 20001018 - USE OF SERINE PROTEASE INHIBITORS TO INHIBIT PATHOPHYSIOLOGY AND NEUROPATHOLOGY IN A HOST
Title (en)
USE OF SERINE PROTEASE INHIBITORS TO INHIBIT PATHOPHYSIOLOGY AND NEUROPATHOLOGY IN A HOST
Title (de)
VERWENDUNG VON SERINPROTEASEINHIBITOREN ZUR HEMMUNG DER PATHOPHYSIOLOGIE UND DER NEUROPATHOLOGIE IN EINEM WIRT
Title (fr)
UTILISATION D'INHIBITEURS DE SERINE PROTEASE POUR INHIBER LA PATHOPHYSIOLOGIE ET LA NEUROPATHOLOGIE CHEZ UN HOTE
Publication
Application
Priority
- US 9900465 W 19990108
- US 7073698 P 19980108
Abstract (en)
[origin: WO9934789A1] Methods are provided for inhibiting cell adhesion molecule cleavage in brain tissue of a host. In the subject methods, an effective amount of a protease inhibitor, particularly serine protease inhibitors, such as those that inhibit tPA and related proteases, is administered to the host. The subject methods find use in the treatment and prevention of pathophysiology and neuropathology in a host, such as the treatment of a variety of pathological conditions resulting from pathophysiology and/or excitotoxicity. Specific pathological conditions in which the subject methods find use include epilepsy (and related seizure states) and neuronal damage associated with excessive glutamate activity, e.g. resulting from an acute event such as hypoxia, head trauma or stroke.
IPC 1-7
A61K 31/135; A61K 38/55; A61K 38/57; A61K 31/185; A61P 25/08
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/135 (2006.01); A61K 31/185 (2006.01); A61K 38/55 (2006.01); A61K 38/57 (2006.01); A61P 25/08 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61P 25/08 (2017.12)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9934789 A1 19990715; AU 2110099 A 19990726; EP 1043987 A1 20001018; EP 1043987 A4 20040331
DOCDB simple family (application)
US 9900465 W 19990108; AU 2110099 A 19990108; EP 99901395 A 19990108