Global Patent Index - EP 1043987 A1

EP 1043987 A1 2000-10-18 - USE OF SERINE PROTEASE INHIBITORS TO INHIBIT PATHOPHYSIOLOGY AND NEUROPATHOLOGY IN A HOST

Title (en)

USE OF SERINE PROTEASE INHIBITORS TO INHIBIT PATHOPHYSIOLOGY AND NEUROPATHOLOGY IN A HOST

Title (de)

VERWENDUNG VON SERINPROTEASEINHIBITOREN ZUR HEMMUNG DER PATHOPHYSIOLOGIE UND DER NEUROPATHOLOGIE IN EINEM WIRT

Title (fr)

UTILISATION D'INHIBITEURS DE SERINE PROTEASE POUR INHIBER LA PATHOPHYSIOLOGIE ET LA NEUROPATHOLOGIE CHEZ UN HOTE

Publication

EP 1043987 A1 (EN)

Application

EP 99901395 A

Priority

  • US 9900465 W
  • US 7073698 P

Abstract (en)

[origin: WO9934789A1] Methods are provided for inhibiting cell adhesion molecule cleavage in brain tissue of a host. In the subject methods, an effective amount of a protease inhibitor, particularly serine protease inhibitors, such as those that inhibit tPA and related proteases, is administered to the host. The subject methods find use in the treatment and prevention of pathophysiology and neuropathology in a host, such as the treatment of a variety of pathological conditions resulting from pathophysiology and/or excitotoxicity. Specific pathological conditions in which the subject methods find use include epilepsy (and related seizure states) and neuronal damage associated with excessive glutamate activity, e.g. resulting from an acute event such as hypoxia, head trauma or stroke.

IPC 1-7 (main, further and additional classification)

A61K 31/135; A61K 31/185; A61K 38/55; A61K 38/57; A61P 25/08

IPC 8 full level (invention and additional information)

A61K 31/135 (2006.01); A61K 31/00 (2006.01); A61K 31/185 (2006.01); A61K 38/55 (2006.01); A61K 38/57 (2006.01); A61P 25/08 (2006.01)

CPC (invention and additional information)

A61K 31/00 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9934789 A1 19990715; AU 2110099 A 19990726; EP 1043987 A1 20001018; EP 1043987 A4 20040331

INPADOC legal status


2011-10-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: A61K 31/135 20060101AFI20110914BHEP

2011-10-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: A61K 38/55 20060101ALI20110914BHEP

2011-10-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: A61K 38/57 20060101ALI20110914BHEP

2011-10-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: A61K 31/185 20060101ALI20110914BHEP

2011-10-19 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: A61P 25/08 20060101ALI20110914BHEP

2006-05-31 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051130

2004-03-31 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20040213

2004-03-24 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 31/135 A

2004-03-24 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 38/55 B

2004-03-24 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 38/57 B

2004-03-24 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 31/185 B

2004-03-24 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61P 25/08 B

2000-11-22 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: THURIS CORPORATION

2000-11-22 [RIN1] INVENTOR (CORRECTION)

- Inventor name: THURIS CORPORATION

2000-10-18 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000804

2000-10-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE