Global Patent Index - EP 1044274 A2

EP 1044274 A2 2000-10-18 - ADENOVIRAL VECTORS WITH MODIFIED CAPSID PROTEINS

Title (en)

ADENOVIRAL VECTORS WITH MODIFIED CAPSID PROTEINS

Title (de)

ADENOVIRALE VEKTOREN MIT MODIFIZIERTEN KAPSID PROTEINE

Title (fr)

VECTEURS D'ADENOVIRUS COMPRENANT DES PROTEINES CAPSIDIQUES MODIFIEES

Publication

EP 1044274 A2 (EN)

Application

EP 99903122 A

Priority

  • US 9900913 W
  • US 7167498 P

Abstract (en)

[origin: WO9936545A2] The present invention is directed to adenoviral vectors having modified capsid proteins which comprise heterologous ligands that improve and/or alter the infectious capability of the vector. Such ligands are capable of binding to target cells, and their inclusion into adenoviral vectors facilitates the binding and infectious properties of the vectors. In a preferred embodiment, the ligands are peptides, and the target cells are epithelial cells. The invention is also directed to novel heterologous ligands, to ligand-receptor complexes, and to compositions comprising the adenoviral vectors of the invention. Additional aspects of the invention include methods to use the adenoviral vectors of the invention to deliver transgenes to target cells.

IPC 1-7 (main, further and additional classification)

C12N 15/34; A61K 48/00; C07K 14/075; C12N 15/86

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); C07K 14/075 (2006.01); C12N 7/00 (2006.01); C12N 15/34 (2006.01); C12N 15/861 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10345 (2013.01); C12N 2810/40 (2013.01); C12N 2810/405 (2013.01); C12N 2810/60 (2013.01); C12N 2810/6018 (2013.01)

Citation (search report)

See references of WO 9936545A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9936545 A2 19990722; WO 9936545 A3 19991104; AU 2321999 A 19990802; CA 2317941 A1 19990722; EP 1044274 A2 20001018; JP 2002508967 A 20020326

INPADOC legal status


2004-02-11 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030801

2000-10-18 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000816

2000-10-18 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE