EP 1044274 A2 20001018 - ADENOVIRAL VECTORS WITH MODIFIED CAPSID PROTEINS
Title (en)
ADENOVIRAL VECTORS WITH MODIFIED CAPSID PROTEINS
Title (de)
ADENOVIRALE VEKTOREN MIT MODIFIZIERTEN KAPSID PROTEINE
Title (fr)
VECTEURS D'ADENOVIRUS COMPRENANT DES PROTEINES CAPSIDIQUES MODIFIEES
Publication
Application
Priority
- US 9900913 W 19990115
- US 7167498 P 19980116
Abstract (en)
[origin: WO9936545A2] The present invention is directed to adenoviral vectors having modified capsid proteins which comprise heterologous ligands that improve and/or alter the infectious capability of the vector. Such ligands are capable of binding to target cells, and their inclusion into adenoviral vectors facilitates the binding and infectious properties of the vectors. In a preferred embodiment, the ligands are peptides, and the target cells are epithelial cells. The invention is also directed to novel heterologous ligands, to ligand-receptor complexes, and to compositions comprising the adenoviral vectors of the invention. Additional aspects of the invention include methods to use the adenoviral vectors of the invention to deliver transgenes to target cells.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); C07K 14/075 (2006.01); C12N 7/00 (2006.01); C12N 15/34 (2006.01); C12N 15/861 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10345 (2013.01); C12N 2810/40 (2013.01); C12N 2810/405 (2013.01); C12N 2810/60 (2013.01); C12N 2810/6018 (2013.01)
Citation (search report)
See references of WO 9936545A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9936545 A2 19990722; WO 9936545 A3 19991104; AU 2321999 A 19990802; CA 2317941 A1 19990722; EP 1044274 A2 20001018; JP 2002508967 A 20020326
DOCDB simple family (application)
US 9900913 W 19990115; AU 2321999 A 19990115; CA 2317941 A 19990115; EP 99903122 A 19990115; JP 2000540247 A 19990115