Global Patent Index - EP 1044690 A1

EP 1044690 A1 20001018 - Applications of gamma globulin-rich plasma protein mixtures of animal origin and process for the preparation thereof

Title (en)

Applications of gamma globulin-rich plasma protein mixtures of animal origin and process for the preparation thereof

Title (de)

Anwendung und Herstellungsverfahren von tierischen Gammaglobulin-reichen Plasmaprotein Mischungen

Title (fr)

Utilisation et procédé de préparation de mélanges de protéines plasmatiques d'origine animale riches en gamma-globulines

Publication

EP 1044690 A1 20001018 (EN)

Application

EP 00500066 A 20000412

Priority

  • ES 9900757 A 19990413
  • ES 200000933 A 20000411

Abstract (en)

The invention concerns applications of mixtures of gamma globulin-rich plasma proteins of animal origin for the preparation of medicinal compositions, food and dietary preparations: ÄaÜ suitable for the prevention and treatment of gastrointestinal disorders in human beings and animals; ÄbÜ suitable for improving the immunological state of human beings and animals; ÄcÜ suitable for the treatment of malabsorption processes in human beings and animals, and ÄdÜ suitable for the treatment of clinical conditions accompanied by malnutrition in human beings and animals and a process for the preparation of the above mixtures comprising diluting a first gamma globulin concentrate in water at a ratio of 1:7 - 1:11; adjusting the pH to 3-6; adding polyethylene glycol at a rate of 2-6 wt%; centrifuging at an acceleration of 3000-11000 g to give a first clarified gamma globulin-rich fraction, which is separated; adjusting the pH thereof to 6-9, adding of a further amount of polyethylene glycol at a rate of 6-12 wt%; centrifuging for a second time at an acceleration of 3000-11000 g to give a second insolubilized fraction, comprising mainly gamma globulin and a second clarified fraction, which are separated.

IPC 1-7

A61K 39/395; A61K 35/16; A61P 1/00

IPC 8 full level

C07K 16/06 (2006.01)

CPC (source: EP)

A61P 1/00 (2018.01); C07K 16/065 (2013.01); A61K 2039/505 (2013.01)

Citation (search report)

  • [XY] EP 0064210 A1 19821110 - CUTTER LAB [US]
  • [XY] US 5531989 A 19960702 - PAUL STEPHEN M [US]
  • [Y] EP 0338229 A1 19891025 - BIOTEST PHARMA GMBH [DE]
  • [Y] SU 1754113 A1 19920815 - MO NII EPIDEMIOLOGII MIKROBIOL [SU], et al
  • [XY] HASKO F. ET AL.: "Fractionation of plasma proteins with PEG.", HAEMATOLOGICA, vol. 14, no. 2, 1981, Budapest, pages 199 - 206, XP000917117
  • [Y] PATENT ABSTRACTS OF JAPAN vol. 013, no. 169 (C - 587) 21 April 1989 (1989-04-21)
  • [XY] PATENT ABSTRACTS OF JAPAN vol. 013, no. 556 (C - 664) 11 December 1989 (1989-12-11)
  • [Y] BPI, VFA, BAH, VAP: "Rote Liste 1999", 1999, ECV, AULENDORF, XP002144418
  • [Y] TRUSOVA L. ET AL.: "Fractionation of blood serum proteins by non-ionic water-soluble polymers.", VSES. GOS. NAUCHNO-KONTROL'N. INST. VET. PREP., 1980, pages 98 - 101, XP002144417

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

EP 1044690 A1 20001018; EP 1044690 B1 20050803; AT E300956 T1 20050815; DE 60021644 D1 20050908; ES 2243223 T3 20051201

DOCDB simple family (application)

EP 00500066 A 20000412; AT 00500066 T 20000412; DE 60021644 T 20000412; ES 00500066 T 20000412